Ac-DMQD-CHO (trifluoroacetate salt) (Synonyms: Ac-Asp-Met-Gln-Asp-CHO, Caspase-3 Inhibitor) |
| Catalog No.GC42688 |
Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM). It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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