Ubiquitination/ Proteasome

ATG7-IN-2 (Compound 1) is an effective inhibitor of ATG7 with an IC50 value of 0.089 μM. ATG7-IN-2 can inhibit the autophagy marker LC3B.

Forigerimod TFA (IPP-201101 TFA) is a CD4 T cell regulator. Forigerimod TFA is a 21 amino acid fragment of U1 small nuclear ribonucleoprotein 70 kDa, phosphorylated at the Ser140 site. Forigerimod TFA can effectively inhibit autophagy. Forigerimod TFA can be used for research on autoimmune diseases such as systemic lupus erythematosus (SLE).

HDAC10-IN-2 hydrochloride (compound 10c) is an effective and highly selective HDAC10 inhibitor with an IC50 of 20 nM. HDAC10-IN-2 hydrochloride can regulate autophagy in invasive FLT3-ITD positive acute myeloid leukemia cells.

Paeonol-d3 is deuterated Paeonol.

4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide.

HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM.

Zetomipzomib (KZR-616) maleate, a first-in-class immunoproteasome inhibitor, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP2/mLMP2) subunits of the immunoproteasome.

AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor.

Obeticholic acid-d5 is the deuterium labeled Obeticholic acid.

FiVe1 is a potent vimentin (VIM; the intermediate filament and mesenchymal marker) inhibitor.

Desethyl Amiodarone-d4 (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride.

AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC).

AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC).

Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe.

DCAP is a broad-spectrum antibiotic targeting the membranes of both Gram-positive and Gram-negative bacteria.

PARL-IN-1 is a potent PARL inhibitor with an IC50 value of 28 nM.

Cabergoline-d5 is the deuterium labeled Cabergoline.

Dox-btn2 is a biotinylated derivative of Doxorubicin , with a biotin label at the point of conjugation to doxorubicin at 3'-NH2.

Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor.

LU-002i is a subunit-selective human proteasome β2c and β2i inhibitor with an IC50 value of 220 nM for β2i.

ATTECs Degrader 1 (Compound MT1) is an ATTECs compound.

VCP Activator 1 is a VCP activator that dose-dependently stimulates VCP ATPase activity.

MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity.

WJ-39 is an orally active aldose reductase (AR) inhibitor.