Ubiquitination/ Proteasome

Clemastine-d5 (fumarate) is the deuterium labeled Clemastine fumarate.

Felodipine-d3 is the deuterium labeled Felodipine.

Maprotiline-d5 (hydrochloride) is the deuterium labeled Maprotiline hydrochloride.

Paroxetine-d4 (hydrochloride) is deuterium labeled Paroxetine (hydrochloride).

Leonurine is an alkaloid isolated from Leonurus artemisia, with anti-oxidative and anti-inflammatory.

Alphitolic acid, a pentacyclic triterpenoid with a lupane skeleton, exhibits anti-inflammatory and cytotoxic activities.

Hydroxychloroquine-d4-1 (sulfate) is the deuterium labeled Hydroxychloroquine.

XIE62-1004-A is an inducer of p62-LC3 interaction.

Tempol-d17,15N is the deuterium labeled Tempol.

6-CEPN is a RAS inhibitor.

AMDE-1 is a potent autophagy inducer.

BC-23 (NSC 45382) is a proteasome inhibitor.

DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis.

Pazopanib-13C,d3 (drochloride) is the deuterium and 13C labeled Pazopanib drochloride.

NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol.

Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib.

(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (another component is (cis)-ML-SI3) that targets three isoforms of TRPML.

HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM

CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A.

FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 is a linker of AUTAC4.

CUR5g is a potent autophagy inhibitor.

Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor useful in solid tumor research, especially breast cancer.

Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor , a F508del CFTR corrector.

UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM.