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Proteasome

The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.

  1. Cat.No. Product Name Information
  2. GC41233 (R)-MG132

    The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins.

  3. GC10102 Aclacinomycin A Topoisomerase I and II inhibitor
  4. GC35238 Aclacinomycin A hydrochloride
  5. GC33743 Alicapistat (ABT-957)
  6. GC13789 AM 114

    20S proteasome inhibitor

  7. GC12784 Artemether (SM-224)

    Semi-synthetic derivative of artemisinin

  8. GC17644 Bortezomib (PS-341) Proteasome Inhibitor
  9. GC12527 Calpain Inhibitor I, ALLN Calpain I/II/ B/L inhibitor
  10. GC10342 Calpeptin Ca2+-dependent protease,calpain inhibitor
  11. GC32815 Capzimin
  12. GC15089 Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog
  13. GC15083 Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent
  14. GC12272 CEP-18770

    Proteasome inhibitor

  15. GC16581 Clasto-Lactacystin β-lactone Proteasome inhibitor
  16. GC16747 Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative
  17. GC12494 Epoxomicin Proteasome inhibitor
  18. GC31563 FK-448 Free base
  19. GC13711 Gabexate mesylate Trypsin-like serine proteinases inhibitor
  20. GC17255 Gliotoxin

    20S proteasome inhibitor

  21. GC16699 HMB-Val-Ser-Leu-VE inhibitor of the trypsin-like activity of the 20S proteasome

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