Membrane Transporter/Ion Channel

L-R4W2 acetate is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1 ), with an IC 50 of 0.1 μM.

HKC54 is a selective TRPV2 antagonist with an IC 50 of 0.4 μM.

FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex.

FP802 dihydrochloride is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex.

PSFL2915 is a selective, orally active P2X receptor inhibitor with oral effectiveness, with an IC 50 of 0.319 μM for human P2X3, 0.261 μM for rat P2X2/3, and 13.3 μM for human P2X2.

PSB-10211 is a P2X2 receptor antagonist with an IC 50 of 0.086 μM against rat P2X2 receptors.

VU6080824 (hydrochloride), a derivative of ML-133, is an inward-rectifier potassium channel (K ir 2.1) inhibitor with an IC 50 of 0.35 μM.

LY3972406 hydrochloride is a kv1.3 potassium channel inhibitor without affecting hERG channel activity.

IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a K D of 4.63 μM.

Kir4.1-IN-1 (Compound 37) is a potent, selective, blood-brain barrier permeable Kir4.1 inhibitor with an IC 50 of 0.19 μM.

QO-83, Retigabine analogue, is a voltage-gated potassium channel KCNQ2 (Kv7.2) activator with an EC 50 of 0.56 μM.

WO662 (compound I-1a) is a KCNT1 inhibitor with an IC 50 ≤ 250 nM.

ShK toxin TFA (Stichodactyla helianthus neurotoxin TFA) is a neurotoxin.

E0199 is a novel potent dual-target K V 7/Na V modulator that activates the K V 7 channel (K V 7.2/7.3 ( EC 50 = 12.78 nM), K V 7.2 ( EC 50 = 0.50 μM), and K V 7.5 ( EC 50 = 27.14 nM) channels) while simultaneously blocks the Na V 1.7 ( IC 50 = 0.52 μM), Na V 1.8 ( IC 50 = 0.24 μM), and Na V 1.9 ( IC 50 = 0.16 μM) channels.

Zastaprazan (JP-1366) citrate is a Proton pump inhibitor and potent potassium-competitive acid blocker.

MK-5661 is an orally potent Na V 1.8 voltage-gated sodium channel inhibitor with an EC 50 of 4.3 nM.

Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation.

Nav1.7-IN-19 is a potent, selective and orally active Nav1.7 inhibitor with an IC 50 of 0.49 μM.

FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC 50 1540 μM, NHERF1 PDZ2 IC 50 160 μM, and Frizzled-7-Dishevelled PDZ complex K i 10 μM.

HK2-IN-4 is a selective hexokinase 2 ( HK2 ) inhibitor with an IC 50 value of 0.79 μM and a K d value of 0.41 μM.

ATX-012 is an ionizable cationic lipid for the assembly of mRNA -delivering lipid nanoparticles (LNPs).

Alofropodect is an orally active, blood-brain barrier permeable phosphodiesterase 10A ( PDE10A ) inhibitor with IC 50 values of 1 nM (Reference 1) and 35 nM (Reference 2).

8-Br-ADPR disodium (8-Bromoadenosine-5'-O-diphosphoribose) is a TRPM2 inhibitor and ADPR signaling pathway antagonist.

4''-Oxoavermectin B1a is a potentiator targeting GABA (γ-aminobutyric acid) and glutamate-gated chloride channels with insecticidal and acaricidal activities.