Membrane Transporter/Ion Channel

(S)-IDOR-1117-2520 is the S-isomer of IDOR-1117-2520.

ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor.

Suzetrigine N-oxide (the third compound in P57) is a derivative of Suzetrigine.

JNJ 303 -d 3 is the deuterium labeled JNJ 303.

Pregnenolone -d 6 (3β-Hydroxy-5-pregnen-20-one-d 6 ) is the deuterium labeled Pregnenolone [1] . Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones.

Arecoline-d 5 hydrobromide is the deuterium labeled Arecoline hydrobromide.

(S)-TROX-1 is the S-enantiomer of TROX-1.

Acoltremon -d 3 (WS-12-d 3 ) is the deuterium labeled Acoltremon.

Spironolactone -d 6 -1 is the deuterium labeled Spironolactone.

Anandamide - 15 N (AEA- 15 N) is the 15 N-labeled Anandamide.

Papaveroline is a Fyn tyrosine kinase inhibitor, Na +,K + -ATPase inhibitor with an IC 50 of 0.20 mM, Mg 2+ -ATPase inhibitor, K + -activated pNPPase inhibitor with an IC 50 of 1.51 mM, and apoptosis inducer [1] [2] [3] . Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues [1] . Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels [3] . Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease [3] . Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease [3] .

ART5537 is a selective EXO1 inhibitor with a IC 50 of 3.4 nM and a K d of 6.8 nM.

SZ0232 is a selective mPGES-2 inhibitor.

Creatine transporter-IN-1 is a synthetic creatine transporter ( CT1/SLC6A8 ) inhibitor.

SLC6A19-IN-4 is an allosteric-competitive and orally active B 0 AT1 inhibitor.

SKLB06489 is a selective and orally active inhibitor of type I PRMT enzymes, with IC 50 values of 64.55 nM ( PRMT1 ), 4.21 nM ( PRMT6 ), and 51.27 nM ( PRMT8 ).

HTS13286 is a novel AQP9 inhibitor.

HCM-01 is an Excitatory amino acid transporter 2 ( EAAT2 ) activator with oral effectiveness and blood-brain barrier penetration.HCM-01 binds to the allosteric site of EAAT2, increases EAAT2 expression in astrocytes, enhances glutamate-handling capacity, and modulates glutamate homeostasis.HCM-01 acts as an antioxidant, improves oxidative/antioxidative balance and increases total antioxidant capacity.

2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine.

Piezo1 agonist 2 (Compound PD2) is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 conjugate that utilizes LAT1.

Anti-ZnT8 Antibody (mAb43) is a monoclonal antibody targeting the zinc transporter ZnT8, with islet-specific biodistribution characteristics.

Atidafonat is an orally active sodium-dependent phosphate transporter inhibitor, with IC 50 values of 6.8, 1.5, and 1.7 μM against human NaPi-IIb, PiT-1, PiT-2, respectively; and IC 50 values of 3.9, 1.9, and 1.7 μM against rat NaPi-IIb, PiT-1, PiT-2, respectively.

S-D-Lactoylglutathione (S-Lactylglutathione; (R)-S-Lactoylglutathione) is a multifunctional metabolic intermediate of the glyoxalase system.

YHV98-4 is a selective, blood-brain barrier-permeable Hv1 inhibitor with an IC 50 of 0.7 μM.