MAPK Signaling

PAR2 modulator-1 is a biased protease-activated receptor 2 ( PAR2 ) inhibitor.

RM-046 is an orally active, selective ternary complex inhibitor of KRAS Q61H (active form).

SHY-867 is a pan RAS inhibitor.

SHY-855 is a pan RAS inhibitor.

RNK08954 is an orally active KRAS G12D inhibitor with a K d of 0.0395 nM.

Eras-4001 is a potent, orally active pan- KRAS inhibitor with K d values of 110, 13 and 39 pM against wild-type, G12D and G12V mutant KRAS, respectively, and exhibits selectivity toward wild-type HRAS and NRAS.

KRAS G12D-IN-30 (Compound 4) is a KRAS inhibitor.

HTL-9936 is an orally active partial agonist of muscarinic M1 receptor.

BMS-986331 is an orally active selective N-Formyl Peptide Receptor 2 (FPR2) agonist with an EC 50 of 0.5 nM in humans and 1 nM in rats.

HDB-1 is a selective inhibitor of the P2Y14 receptor ( P2Y14R ) with an IC 50 of 26 pM.

ETI41 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 ( IC 50 = 0.63 μM) and TLR9 ( IC 50 = 0.16 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5).

ETI60 is an orally active, selective TLR inhibitor that targets the nucleoside-binding Site I on TLR7 ( IC 50 = 0.68 μM) and TLR9 ( IC 50 = 0.12 μM), sparing surface TLRs (including TLR1/TLR2, TLR2/TLR6, TLR4 and TLR5).

MyD88-IN-3 is an orally active, selective MyD88 Inhibitor.

IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor.

Anti-IL11 Antibody (X203, Mouse IgG ) is an antibody targeting IL-11.

Anti-Human/Mouse Amphiregulin Antibody (AR37) is an antibody targeting amphiregulin ( AREG ), with a K d value of 3.24 nM for the human protein and 6.40 nM for the mouse protein.

AZ14289671 is an orally active, blood-brain barrier-penetrant tyrosine kinase ( tyrosine kinase ) inhibitor (TKI) that specifically targets non-small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations ( EGFR Exon20Ins ), while largely sparing wild-type EGFR to reduce off-target toxicities such as rash and diarrhea.

AT-051/43421517 is a cytoprotective agent and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 ( hPgk1 ).

(E/Z)-ASK1-IN-4 is an isomer of ASK1-IN-4.

MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator.

ETC-501 is a blood-brain barrier-permeable, orally active, and selective MNK1 / MNK2 inhibitor, with an IC 50 of 0.033 μM against MNK1 and 0.111 μM against MNK2.

KZ-02 is an orally active dual MEK1 / Pim-1 kinase inhibitor, with an IC 50 of 1.07 nM against MEK1 and an IC 50 of 1.34 μM against Pim-1.

TAO Kinase-IN-3 is a potent pan- TAOK ( Thousand-And-One Kinase ) inhibitor that specifically binds to and inhibits the kinase activities of TAOK1, TAOK2 and TAOK3 with K d values of <0.17 nM, 0.34 nM, and 0.17 nM, respectively.

MNK-IN-5 is a MNK inhibitor that suppresses MNK activity [1] .