PI3K/Akt/mTOR Signaling

A heterocyclic building block

A heterocyclic building block

A building block

An internal standard for the quantification of everolimus

A neuropeptide with diverse biological activities

An internal standard for the quantification of rapamycin

VS-5584 analog is a dimethyl analog of VS-5584 which is an potent and selective mTOR/PI3K dual inhibitor with pyrido [2,3-d] pyrimidine structure.

Kaempferol 3-O-galactoside (Trifolin) is a derivative of flavonoid, which is isolated from the aerial part of Consolida oliveriana.

MDK34597 (compound 35) is a potent PI3K p110α inhibitor with an pIC50 of 6.85.

A GSK3 inhibitor

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

PI 3-kinase δ inhibitor

Potent and selective PI 3-kinase δ inhibitor; orally bioavailable

A building block

A peptide substrate for Akt

An Akt peptide substrate

MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects.

N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases thephosphorylationlevels of Akt and p38MAPK.

SKI V is a noncompetitive and potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with an IC50 of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC50 of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity.

Disitertide TFA is a specific inhibitor of transforming growth factor β1 (TGF-β1) receptor type I.

A glucoside chalcone with diverse biological activities

An internal standard for the quantification of metformin

Quercetin D5 is a deuterated internal standard for the natural compound quercetin, its chemical structure is essentially the same as quercetin, except that five deuterium (D) atoms replace five hydrogen (H) atoms in the A ring.