PI3K/Akt/mTOR Signaling

3-Methyladenine-d3 is the deuterated form of 3-Methyladenine. 3-Methyladenine (3-MA) is an inhibitor of PI3K. It is widely used as an autophagy inhibitor by inhibiting class III PI3K.

ABC1183 is a selective dual inhibitor of GSK3 and CDK9 with oral activity. Its IC50 values for GSK3β, GSK3α, and CDK9/cyclin T1 are 657 nM, 327 nM, and 321 nM respectively. ABC1183 has anti-inflammatory properties as well as anti-tumor activity.

ALM301 is a highly specific AKT inhibitor with oral activity. Its IC50 values for AKT1, AKT2 and AKT3 are 0.13 μM, 0.09 μM and 2.75 μM, respectively. ALM301 inhibits the phosphorylation of AKT and regulates downstream signaling in vitro. It can inhibit cancer cell proliferation and tumor growth.

BRD0209 is an effective, selective, and dual inhibitor of GSK3α/β (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM). It is also a reversible ATP-competitive inhibitor with fast kinetics (Ki values of 4.2 nM for both isoforms). BRD0209 is a tricyclic pyrazolone-fused tetrahydroquinoline compound. It has potential in researching mood disorders.

Dihydroevocarpine induces acute myeloid leukemia cell toxicity by inhibiting mTORC1/2 activity.

GSK3-IN-3 is a mitophagy inducer that can induce Parkin-dependent mitochondrial autophagy. It is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 has non-ATP and non-substrate competitive properties and has neuroprotective effects on 6-OHDA.

GSK3 Substrate, α, β subunit is a peptide substrate of glycogen synthase kinase-3 (GSK-3) that can be used to measure GSK-3 activity.

HTH-01-091 is a potent and selective inhibitor of maternal embryonic leucine zipper kinase (MELK), with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be used for breast cancer research.

Insulin Detemir is an artificial insulin that helps control blood sugar levels. It works by activating the -cat and CREB signaling pathways, which depend on Akt and extracellular signal-regulated kinase (ERK), to promote Gcg expression and stimulate GLP-1 secretion. Insulin Detemir can be used in research for type 2 diabetes.

Leucine-13C6 is a 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA) that can activate the mTOR signaling pathway.

PI3K/AKT-IN-1 is a potent PI3K/AKT dual inhibitor with IC 50 values of 6.99μM, 4.01μM, and 3.36μM for PI3Kγ, PI3Kδ and AKT, respectively.

PI3K-IN-30 (compound 6d) is an effective PI3K inhibitor with IC50 values of 5.1 nM, 136 nM, 30.7 nM and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ respectively.

PI3K-IN-31 (Compound 6b) is an effective PI3K inhibitor with IC50 values of 3.7 nM, 74 nM, 14.6 nM and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ respectively. It has anti-cancer properties.

PI3K/mTOR Inhibitor-11 is an orally active inhibitor of PI3K/mTOR (with IC50 values of 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR, respectively). It regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 protein. PI3K/mTOR Inhibitor-11 can be used in cancer research.

PI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositide 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual disorders, solid tumors, and idiopathic pulmonary fibrosis (IPF).

PIKfyve-IN-1 is an efficient and cell-active chemical probe that can inhibit phosphoinositide 3-phosphate 5-kinase (PIKfyve) with an IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the study of PIKfyve in virology.

PKD-IN-1 dihydrochloride (compound 32) is an aminoethylaminobenzyl (AEAA) compound that can be used as a PKD-1 inhibitor. PKD-IN-1 can be used in research on diseases mediated by protein kinase D (PKD).

Pifusertib (TAS-117) hydrochloride is an effective, selective, and orally active isoform Akt inhibitor (with IC50 values of 4.8, 1.6, and 44 nM for Akt1, 2, and 3 respectively). Pifusertib hydrochloride stimulates anti-myeloma activity and enhances lethal endoplasmic reticulum stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy in cells.