PI3K/Akt/mTOR Signaling

Vulolisib is an effective and orally active phosphoinositide 3-kinase (PI3K) inhibitor with IC50 values of 0.2 nM, 168 nM, 90 nM, and 49 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively. It has anti-proliferative activity against cancer cells and also exhibits anti-tumor activity.

MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM.

Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa.

PF-739 is an AMPK activator. PF-739 reduces plasma glucose levels by activating all 12 heterotrimeric AMPK complexes.

P-2281 is a mTOR inhibitor with anticancer and anti-inflammatory efficacies.

6-Me-ATP (N6-Methyl-ATP) trisodium is a N6-modified ATP derivative.

AMPK activator 13 is a potent activator of AMPK.

PITCOIN4 is a highly selective Class II Alpha PI3K-C2α inhibitor.

PXL770 is a direct AMP kinase activator.

SQLE-IN-1 (compound 19) is a squalene epoxidase (SQLE) inhibitor.

Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor.

Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum.

Alphitolic acid, a pentacyclic triterpenoid with a lupane skeleton, exhibits anti-inflammatory and cytotoxic activities.

Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino.

Desmethyl-VS-5584 hydrochloride is a dimethyl analog of VS-5584, a potent and selective dual mTOR/PI3K inhibitor, with a pyridine[2,3-d]pyrimidine structure.

PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively.

PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ.

PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1).

AMDE-1 is a potent autophagy inducer.

(R)-MRT199665 is an isomer of MRT199665.

Biguanide is an orally active antiperglycemic agent.

HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM.

NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol.

AMPK activator 2 (compound 7a) drochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K.