PI3K/Akt/mTOR Signaling

MTORC1 and mTORC2 inhibitor

P110δkinase inhibitor

Triciribine is an adenosine analog that targets protein kinase B (Akt) with an IC 50 value of 130nM and has antitumor activity.

Pan-PI3K/mTOR inhibitor

A selective inhibitor of GSK3β

Deguelin is one of four major naturally occurring rotenoids isolated from root extracts and is best recognized as a NADH: ubiquinone oxidoreductase (complex I) inhibitor, resulting in significant alterations in mitochondrial function.

PI3Kδ inhibitor

specific Akt inhibitor

inhibitor of PI3Kδ

BX517(PDK1 inhibitor2) is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.

Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR 99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR 99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR 99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR 99021 trihydrochloride induces autophagy.

PF-05212384 (PKI-587) is a potent dual PI3K/mTOR inhibitor, exhibiting inhibitory effects against PI3Kα (IC₅₀=0.4nM), PI3Kβ (IC₅₀=6nM), PI3Kγ (IC₅₀=8nM), PI3Kδ (IC₅₀=6nM), and mTOR (IC₅₀=1.4nM).

Quercetin dihydrate is the dihydrate form of the flavonoid quercetin, which possesses various biological activities.

PI3Kδ inhibitor,potent and selective

Perifosine is an inhibitor of Akt .

mTORC1 and mTORC2 inhibitor

CDKs and GSK3β inhibitor

PP242 (PP 242) is a selective and ATP-competitive mTOR inhibitor with an IC50 of 8 nM. PP242 inhibits both mTORC1 and mTORC2 with IC50s of 30 nM and 58 nM, respectively.

PI3Kβ inhibitor,potent,selective and ATP competitive

RSK (p90 ribosomal S6 kinase) inhibitor

A pan inhibitor of class I PI3K isoforms

740 Y-P is a potent, cell-permeable activator of phosphoinositide 3-kinase (PI3K).

GSK-3β inhibitor