PI3K/Akt/mTOR Signaling

MK-2206 dihydrochloride is a pan-AKT allosteric inhibitor that inhibits AKT1 (IC 50 =8nM), AKT2 (IC 50 =12nM), and AKT3 (IC 50 =65nM).

AKT Kinase Inhibitor is a potent inhibitor of Akt kinase with antitumor activity.

PI-103 Hydrochloride is a potent cell-permeable multi-target inhibitor that primarily acts on the PI3K and mTOR signaling pathways.

AZD8055 is a new ATP-competitive mTOR inhibitor with an IC 50 of 0.8 nmol/L and a K i of 1.3 nmol/L.

pan-AKT inhibitor

An mTOR inhibitor

AMPK activator

NUAK1/2 inhibitor, potent and selective

A JAK3 inhibitor

pan-RSK inhibitor

GSK-3β inhibitor, potent

mTOR/DNA-PK inhibitor

CHIR-99021 (CT99021) is a kind of highly selective inhibitor of GSK-3, the IC 50 values for GSK-3α and GSK-3β are 10nM and 6.7nM respectively.

PI3Kβ inhibitor,potent and selective

PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis.

4,5,6,7-Tetrabromobenzimidazole is a selective and ATP competitive CK2 (casein kinase 2) inhibitor.

A potent and selective inhibitor of GSK3

PI3K inhibitor,potent selective

AMPK activator, selective

(+)-Usniacin is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usniacin inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity. (+)-Usniacin possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium.

potent, brain-penetrant PI3K inhibitor

Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research.

GSK-3 inhibitor

SU6656 is a small-molecule indolinone that selectively inhibits Src, Yes, and Fyn at IC 50 values of 0.28μM, 0.02μM, and 0.17μM, respectively.