Maresin 2 (Synonyms: 3R,14S-diHDHA) |
Catalog No.GC40980 |
Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1639809-46-3
Sample solution is provided at 25 µL, 10mM.
Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA. [3] At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%. [3] Analytical and biological comparisons of synthetic MaR2 with endogenously derived MaR2 have confirmed its identity as matching the natural product.[4]
Reference:
[1]. Su, H.-M. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J. Nutr. Biochem. 21(5), 364-373 (2010).
[2]. Wu, T.C., and Chen, P.H. Health consequences of nutrition in childhood and early infancy. Pediatr. Neonatol. 50(4), 135-142 (2009).
[3]. Deng, B., Wang, C.W., Arnardottir, H.H., et al. Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. PLoS One 9(7), (2014).
[4]. Serhan, C. . (2007).
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