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Home >> Signaling Pathways >> Proteases >> Lipoxygenase

Lipoxygenase

Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Targets for  Lipoxygenase

Products for  Lipoxygenase

  1. Cat.No. Product Name Information
  2. GC47575 Loratadine-d5 An internal standard for the quantification of loratadine Loratadine-d5 Chemical Structure
  3. GC33907 LP117 LP117 is a novel and potent inhibitor of 5-Lipoxygenase (5-LO) product synthesis with an IC50 of 1.1 μM. LP117 Chemical Structure
  4. GC30610 LY 178002

    LY 178002 is a potent inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2, with IC50 of 0.6 μM for 5-lipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

     LY 178002 Chemical Structure
  5. GC36516 Lycopodine Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine Chemical Structure
  6. GC91594 LYS-006 (hydrochloride) LYS-006 is an inhibitor of leukotriene A4 (LTA4) hydrolase. LYS-006 (hydrochloride) Chemical Structure
  7. GC14751 Malotilate

    NKK-105

     Stimulates hepatocyte regeneration Malotilate Chemical Structure
  8. GC47598 Maresin 1-d5

    7(R)-MaR1-d5, 7(R)-Maresin 1-d5

     A neuropeptide with diverse biological activities Maresin 1-d5 Chemical Structure
  9. GC40980 Maresin 2

    3R,14S-diHDHA

    Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.

     Maresin 2 Chemical Structure
  10. GC47599 Maresin 2-d5

    13R,14S-diHDHA-d5, 13R,14S-dihydroxy Docosahexaenoic Acid-d5, MaR2-d5

     A neuropeptide with diverse biological activities Maresin 2-d5 Chemical Structure
  11. GC69434 Masoprocol

    meso-Nordihydroguaiaretic acid; meso-NDGA

    Masoprocol (meso-Nordihydroguaiaretic acid) is an effective and orally active inhibitor of lipoxygenase. Masoprocol has shown anti-hyperglycemic activity by reducing glucose levels and liver triglyceride concentrations in the body. It has potential for researching type II diabetes.

     Masoprocol Chemical Structure
  12. GC44138 MCTR1

    13-glutathionyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 1, Maresin Sulfido Conjugate 1

     Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. MCTR1 Chemical Structure
  13. GC44139 MCTR2

    13-cysteinylglycinyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 2, Maresin Sulfido Conjugate 2

     Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. MCTR2 Chemical Structure
  14. GC44140 MCTR3

    13-cysteinyl14-hydroxyDocosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 3, Maresin Sulfido Conjugate 3

     Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages. MCTR3 Chemical Structure
  15. GC74159 MK-0731 MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 Chemical Structure
  16. GC44212 MK-886 (sodium salt) Arachidonic acid and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). MK-886 (sodium salt) Chemical Structure
  17. GC36628 ML355 ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. ML355 Chemical Structure
  18. GC70448 MLS000545091 MLS000545091 is a potent and selective lipoxygenase-2 (LOX-2) inhibitor with an IC50 value of 2.6 μM for h15-LOX-2. MLS000545091 Chemical Structure
  19. GC52105 Montelukast

    MK-476

     Montelukast (MK0476 free base) is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (CysLT1). Montelukast Chemical Structure
  20. GC47701 Montelukast-d6 (sodium salt)

    MK-476-d6

     A neuropeptide with diverse biological activities Montelukast-d6 (sodium salt) Chemical Structure
  21. GC47716 Myxochelin A

    (S)-Myxochelin A

     A microbial metabolite with diverse biological activities Myxochelin A Chemical Structure
  22. GC44295 N-acetyl Leukotriene E4

    Nacetyl LTE4

     N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. N-acetyl Leukotriene E4 Chemical Structure
  23. GC44415 N-methyl Leukotriene C4

    Nmethyl LTC4

    Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4.

     N-methyl Leukotriene C4 Chemical Structure
  24. GC18089 Nordihydroguaiaretic acid

    NDGA, NSC 4291

     Nordihydroguaiaretic acid is a potent 5-lipoxygenase (5-LOX) inhibitor with an IC50 value of 8μM. Nordihydroguaiaretic acid Chemical Structure
  25. GC49098 Olsalazine-13C6 An internal standard for the quantification of olsalazine Olsalazine-13C6 Chemical Structure
  26. GC44579 PCTR1

    Protein Conjugates in Tissue Regeneration 1

     Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid. PCTR1 Chemical Structure
  27. GC44580 PCTR2

    Protein Conjugates in Tissue Regeneration 2

     Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid. PCTR2 Chemical Structure
  28. GC44581 PCTR3

    Protein Conjugates in Tissue Regeneration 3

     Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid. PCTR3 Chemical Structure
  29. GC36883 PF-4191834

    PF-04191834

     PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain. PF-4191834 Chemical Structure
  30. GC32038 PGS-IN-1 (KME-4)

    KME-4

     PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM. PGS-IN-1 (KME-4) Chemical Structure
  31. GC61180 Phenidone Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone Chemical Structure
  32. GC45768 Pranlukast-d4

    ONO-1078-d4

     A neuropeptide with diverse biological activities Pranlukast-d4 Chemical Structure
  33. GC40981 Protectin D1

    Neuroprotectin D1, NPD1, PD1

     Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid. Protectin D1 Chemical Structure
  34. GC48993 Protectin D1-d5

    Neuroprotectin D1-d5, NPD1-d5, PD1-d5

     An internal standard for the quantification of protectin D1 Protectin D1-d5 Chemical Structure
  35. GC14847 Psoralidin apoptosis inducer Psoralidin Chemical Structure
  36. GC48035 RCTR1

    Resolvin Glutathione Conjugate in Tissue Regeneration 1, Resolvin Sulfido Conjugate 1

     A specialized pro-resolving mediator RCTR1 Chemical Structure
  37. GC41230 Resolvin D1 methyl ester

    17(S)-Resolvin D1 methyl ester, RvD1 methyl ester

     Resolvin D1 is produced physiologically from the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. Resolvin D1 methyl ester Chemical Structure
  38. GC48041 Resolvin D1-d5

    17(S)Resolvin D1d5, RvD1d5

     An internal standard for the quantification of RvD1 Resolvin D1-d5 Chemical Structure
  39. GC41231 Resolvin D2 methyl ester

    7(S),16(R),17(S)Resolvin D2 methyl ester, RvD2 methyl ester

     Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. Resolvin D2 methyl ester Chemical Structure
  40. GC48042 Resolvin D2-d5

    7(S),16(R),17(S)Resolvin D2d5, RvD2d5

     An internal standard for the quantification of RvD2 Resolvin D2-d5 Chemical Structure
  41. GC41232 Resolvin D3 methyl ester

    RvD3 methyl ester

     Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. Resolvin D3 methyl ester Chemical Structure
  42. GC48043 Resolvin D3-d5

    RvD3-d5

     A neuropeptide with diverse biological activities Resolvin D3-d5 Chemical Structure
  43. GC44818 Resolvin D4

    RvD4

    Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid.

     Resolvin D4 Chemical Structure
  44. GC40982 Resolvin D5

    7(S),17(S)-diHDHA

    Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.

     Resolvin D5 Chemical Structure
  45. GC48044 Resolvin E1-d4

    RvE1d4, 5S,12R,18R-trihydroxy-EPA-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4, 5,12,18R-triHEPE-d4

     A neuropeptide with diverse biological activities Resolvin E1-d4 Chemical Structure
  46. GC48972 Resolvin E2

    RvE2

     A specialized pro-resolving mediator Resolvin E2 Chemical Structure
  47. GC48045 Resolvin E4

    RvE4

     A specialized pro-resolving mediator Resolvin E4 Chemical Structure
  48. GC41189 Ricinelaidic Acid Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). Ricinelaidic Acid Chemical Structure
  49. GC31813 RWJ 63556 RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities. RWJ 63556 Chemical Structure
  50. GC30027 S-(+)-Marmesin ((+)-Marmesin)

    (+)-Marmesin, (S)-Marmesin, NSC 340840

     S-(+)-Marmesin ((+)-Marmesin) is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity. S-(+)-Marmesin ((+)-Marmesin) Chemical Structure
  51. GC31835 S-2474 S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory drug. S-2474 Chemical Structure
  52. GC44879 Sclerotiorin Sclerotiorin is a natural product isolated primarily from Penicillium species. Sclerotiorin Chemical Structure
  53. GC70263 Tebufelone Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone Chemical Structure
  54. GC49386 Tepoxalin

    ORF 20485, RWJ 20485

     A dual inhibitor of COX and 5-LO Tepoxalin Chemical Structure
  55. GC45024 tetranor-12(S)-HETE

    tetranor-12(S)-Hydroxyeicosatetraenoic Acid

     12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. tetranor-12(S)-HETE Chemical Structure
  56. GC10451 U-73122 U-73122 is a potent and selective phospholipase C (PLC) inhibitor with an IC50 value of approximately 1-2.1µM. It also inhibits 5-lipoxygenase (5-LO). U-73122 Chemical Structure
  57. GC41289 U-75302 U-75302 is an LTB4 receptor antagonist with a Ki of 159 nM on guinea pig lung membranes. U-75302 Chemical Structure
  58. GC48659 Umbelliprenin

    7-Farnesyloxycoumarin

     A prenylated coumarin with diverse biological activities Umbelliprenin Chemical Structure
  59. GN10269 Wedelolactone

    IKK Inhibitor II

     Wedelolactone Chemical Structure
  60. GC16014 Zileuton

    A 64077

     Zileuton, a benzothiophene N-hydroxyurea, is an oral inhibitor of 5-Lipoxygenase. Zileuton Chemical Structure
  61. GC14435 Zileuton sodium 5-lipoxygenase and leukotrienes inhibitor Zileuton sodium Chemical Structure
  62. GC48267 Zileuton-d4 An internal standard for the quantification of zileuton Zileuton-d4 Chemical Structure

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