TGF-β / Smad Signaling

CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of G protein-coupled receptor kinase 2 (GRK2) and GRK3 (IC 50 s=18 and 5.4nM, respectively).

K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C.

LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK-1) and ROCK-2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively.

N-Acetylpuromycin is a non-ribotoxic form of the antibiotic puromycin that is formed in puromycin-resistant S.

PKCε Inhibitor Peptide, also called εV1-2, is a protein kinase C ε (PKCε)-derived peptide, act as a selective PKCε inhibitor, inhibits the translocation of PKCε .

An HIV reactivator

SMAD3 Inhibitor, SIS3 is a potent and selective inhibitor of Smad3 phosphorylation.

An internal standard for the quantification of ponatinib

A PKMζ inhibitor

Potent and selective inhibitor of TGF-βRI

Potent TGF-βRI inhibitor

SB-4 is a potent benzoxazole Bone morphogenetic protein 4 (BMP4) signaling agonist with an EC 50 value of 73.64nM.

CRT 0066854 hydrochloride is a potent and selective atypical PKCs inhibitor.

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases.

Isosaponarin is a flavone glycoside isolated from wasabi leaves.

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo. Midostaurin is a multi-targeted protein kinase inhibitor?with?IC50?ranging from 22-500 nM.

Disitertide TFA is a specific inhibitor of transforming growth factor β1 (TGF-β1) receptor type I.

Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide.

Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist.

PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε).

XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects.

ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro.