TGF-β / Smad Signaling

Senkyunolide B is a phthalide found in Angelica sinensis.

OSU-2S TFA is a non-immunosuppressive derivative of Fingolimod hydrochloride (FTY720).

Vevorisertib tetrahydrochloride (ARQ 751 tetrahydrochloride) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation.

A PKC inhibitor

3,3-Dimethyl-1-butanol is an oral inhibitor that inhibits the production of trimethylamine (TMA) by microorganisms and suppresses different microbial TMA lyases.

Oxymatrine is a quinolizidine alkaloid extracted from the roots of Sophora flavescens.

A PKC activator

Asiaticoside is a pentacyclic triterpenoid glycoside extracted from Centella asiatica .

Enzastaurin (LY317615) is an ATP-competitive and selective inhibitor of PKCβ with an IC 50 value of 6nM.

Protein kinase inhibitor

Protein kinase inhibitor

GF 109203X is a selective inhibitor of protein kinase C, selective for the α and β1 isoforms with IC 50 values of 0.0084, 0.0180, 0.210, 0.132, and 5.8μM for α, β1, δ, ε and ζ isoforms of protein kinase C respectively.

Sotrastaurin (AEB071) is a potent and orally-active pan-protein kinase C (PKC) inhibitor, with Ki values of 0.22nM, 0.64nM, 0.95nM, 1.8nM, 2.1nM and 3.2nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.

Go 6983 is a pan-PKC inhibitor that acts on PKCα, PKCβ, PKCγ, PKCδ, andPKCμ with IC 50 values of 7nM, 7nM, 6nM, 10nM, and 20μM, respectively.

Zoledronic Acid is a third-generation nitrogen-containing bisphosphonate bone resorption inhibitor.

ROCK inhibitor

Pirfenidone (AMR69) is an orally active antifibrotic drug that attenuates the production of chemokines CCL2 and CCL12 in fibrocytes .

anti-tumor agent and PKC inhibitor

pan-PKC inhibitor

Midostaurin (PKC412) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits multiple kinases, including FLT3, KIT, PDGFR, and VEGFR (IC 50 = 22-500nM).