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Home >> Signaling Pathways >> TGF-β / Smad Signaling >> Pyk2

Pyk2

Pyk2 is a nonreceptor cytoplasmic protein tyrosine kinase. It is involved in Ca(2+)-induced regulation of ion channel and MAP kinase activation. It plays a role in various cellular events such as cell motility, cell polarization, adhesion, reorganization of actin cytoskeleton etc.

Products for  Pyk2

  1. Cat.No. Product Name Information
  2. GC14767 PF-00562271

    PF-562271;PF00562271;PF62271

     PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase, with an IC50 of 1.5 nM and 13 nM, respectively. PF-00562271 Chemical Structure
  3. GC14407 PF-431396 Pyk2 and FAK inhibitor PF-431396 Chemical Structure
  4. GC15380 PF-562271

    PF562271;PF 562271

     PF-562271 is a potent small-molecule inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (Pyk2) with a IC50 of 1.5 and 14nmol/L, respectively. PF-562271 Chemical Structure
  5. GC10810 PF-562271 HCl

    PF562271 HCl;PF 562271 HCl

     PF-562271 (VS-6062) hydrochloride is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively. PF-562271 HCl Chemical Structure
  6. GC73424 PRT062607 acetate

    P505-15 acetate; PRT-2607 acetate; BIIB-057 acetate

     PRT062607 (P505-15) acetate is an orally available Syk inhibitor (IC50: 1 nM) that inhibits inflammation and induction Apoptosis. PRT062607 acetate Chemical Structure
  7. GC74116 Pyk2-IN-2 Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM. Pyk2-IN-2 Chemical Structure
  8. GC16821 TAE226(NVP-TAE226)

    TAE 226;TAE-226

     TAE226(NVP-TAE226) (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. TAE226(NVP-TAE226) Chemical Structure

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