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TGF-β Receptor

TGF-β receptors (Transforming growth factor-β receptors) are single pass serine/threonine kinase receptors. Transforming growth factor beta (TGF-beta) is a member of a large family of pleiotropic cytokines that are involved in many biological processes, including growth control, differentiation, migration, cell survival, adhesion, and specification of developmental fate, in both normal and diseased states. TGF-beta superfamily members signal through a receptor complex comprising a type II and type I receptor, both serine/threonine kinases.

The type I receptors, referred to as activin receptor-like kinases (ALK), lie at the epicenter of the signaling cascade as they transduce TGF-beta signals to intracellular regulators of transcription known as Smad proteins. ALKs possess an extracellular binding domain, a transmembrane domain, a GS domain that serves as the site of activation by type II receptors, and a kinase domain that activates downstream signaling molecules. ALKs mediate the effect of TGF-beta superfamily on a variety of cellular processes such as proliferation, differentiation, apoptosis, adhesion and migration, and therefore play important roles in many biological processes. Some ALKs have been implicated in several disorders, including tumorigenesis and immune diseases, suggesting that these receptors can be used as drug targets.

Products for  TGF-β Receptor

  1. Cat.No. Product Name Information
  2. GC13927 A 77-01 Potent ALK5 inhibitor
  3. GC10166 A 83-01 ALK-5 inhibitor
  4. GC35210 A 83-01 sodium salt A potent inhibitor of TGF-β type I receptor ALK5 kinase
  5. GC34493 BIBF0775
  6. GC14298 DMH-1 Selective BMP ALK2 receptor
  7. GC17243 Dorsomorphin (Compound C) AMPK inhibitor
  8. GC12560 Dorsomorphin 2HCl AMPK inhibitor
  9. GC13354 EW-7197 Selective inhibitor of TGF-β type I receptor kinase
  10. GC11878 GW788388 ALK5 inhibitor,potent and selective
  11. GC12108 ITD 1 First selective TGFβ inhibitor
  12. GC15567 K02288 ALK inhibitor
  13. GC16580 LDN-193189 ALK inhibitor,potent and selective
  14. GC17035 LDN-212854 BMP receptor inhibitor,potent and selective
  15. GC13225 LDN-214117 potent and selective ALK2 inhibitor
  16. GC36433 LDN193189 Tetrahydrochloride A selective BMP type I receptor inhibitor
  17. GC32728 LSKL, Inhibitor of Thrombospondin TSP-1
  18. GC12363 LY2109761 TβRI/II kinase inhibitor
  19. GC18015 LY2157299 TGF-βR1 inhibitor,potent and selective
  20. GC19234 LY3200882 LY3200882 is a novel and highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
  21. GC11604 LY364947 Inhibitor of TGF-β type I receptor kinase domain

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