Ubiquitination/ Proteasome

Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine.

LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.

MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines.

NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC50s of 47.35 ?M and 56.26 ?M, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway.

Tea polyphenol is the floorboard of phenolic compounds in tea.

BL-918 is an activator of UNC-51-like kinase 1 (ULK1; EC 50 =24.14nM).

TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB that significantly promotes the nuclear translocation of Flag-TFEB with an EC 50 of 2167nM.

Imatinib D8 (STI571 D8) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity.

4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties.

DT2216 is a proteolysis targeting chimera (PROTAC), and targets Bcl-xL for degradation in T-cell lymphomas that depend on the overexpressed proteins of the Bcl-2 family, such as Bcl-2, Bcl-xL, and Mcl-1.

THZ-P1-2 is a potent inhibitor of PI5P4K kinase, with the IC 50 values of 0.95μM and 5.9μM for PI5P4Kα and PI5P4Kβ, respectively.

Malformin A is a cyclopentapeptide fungal metabolite that has been found in A.

Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.

Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam by GC- or LC-MS.

Bosutinib-d8 is intended for use as an internal standard for the quantification of bosutinib by GC- or LC-MS.

(-)-Epigallocatechin gallate-d3/d4 is intended for use as an internal standard for the quantification of (-)-epigallocatechin gallate by GC- or LC-MS.

Curcumin-d6 is intended for use as an internal standard for the quantification of curcumin by GC- or LC-MS.

Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin by GC- or LC-MS.

Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F.

Pentoxifylline is a methylxanthine derivative.

Calpain Inhibitor II (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases.

Asperphenamate is a fungal secondary metabolite originally isolated from A.

Dexamethasone is a corticosteroid compound that has been used as an adjuvant to reduce postoperative pain.

D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0).