Ubiquitination/ Proteasome

L-erythro Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and D-threo sphinganine.

Pinosylvin is a stilbene originally isolated from pine heartwood that has diverse biological activities.

Glycine-β-muricholic Acid is an effective, stable, and arginine-selective oral bioactive FXR inhibitor. It is the glycine-bound form of the murine primary bile acid β-muricholic acid.

2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea.

(R)-MG132 is a proteasome inhibitor with an IC 50 of 100 nM.

Acridine Orange is a cell-permeable, nucleic-acid-selective fluorescent dye. When bound to nucleic acids, Acridine Orange emits fluorescence: upon intercalation into double-stranded DNA produces green fluorescence (excitation 488nm, emission 530nm).

Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase.

Oroxylin A is an active flavonoid with anti-inflammatory, anti-bacterial, anti-viral, and anti-cancer properties.

4-Hydroxy Tolbutamide is the main product of the first-generation sulfonylurea hypoglycemic drug Tolbutamide metabolized by CYP2C9 in the human body.

ABO is a modulator of annexin A7.

Ac-ANW-AMC is a fluorescent substrate for the β5i (LMP7/PSMB8) subunit of the 20S immunoproteasome, with a maximum excitation wavelength of λEx=345nm and a maximum emission wavelength of λEm=445nm.

Ac-PAL-AMC is a fluorescent substrate that is specific to the 20S proteasome LMP2/β1i subunit. The maximum excitation/emission wavelength of the fluorophore 7-amino-4-methylcoumarin (AMC) is 380nm/460nm.

Ac-RLR-AMC is a fluorogenic substrate for the 26S proteasome.

Ac-WLA-AMC is a fluorogenic substrate for the β5c subunit of the 20S proteasome.

Boc-LRR-AMC is a fluorescent substrate for Trypsin, similar to the 20S proteasome.

C18 dihydro Ceramide (d18:0/18:0) is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond.

C8 Ceramide (d18:1.8:0) (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides.

Carfilzomib impurity 13 (hydrochloride) is a potential impurity found in commercial carfilzomib preparations.

Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer.

Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities.

CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP.

Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis.

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.

An anti-protozoal drug used for intestinal and tissue amoebiasis