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(R)-MG132 Catalog No.GC41233

Size Price Stock Qty
1mg
$46.00
In stock
5mg
$167.00
In stock
10mg
$297.00
In stock
25mg
$977.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1211877-36-9 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=CC[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Formula C26H41N3O5 M.Wt 475.6
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or mis-folded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. After treatment for one hour at 100 nM, it inhibits 50% and 31% of proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells, respectively. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities compared to (S)-MG132 (IC50s = 0.22 versus 0.89 &#181M (ChTL); 34.4 versus 104.43 &#181M (TL); 2.95 versus 5.70 &#181M (PGPH), respectively).