TIC10 isomer
Catalog No.: GC10350Purity:>98.00%Synonyms: ONC201 isomer
TIC10 isomer is the analogue of TIC10/ONC201.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 41276-02-2
10mM (in 1mL DMSO)In Stock
$58.00
1
10mgIn Stock
$62.00
1
20mgIn Stock
$100.00
1
50mgIn Stock
$193.00
1
100mgIn Stock
$289.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $58.00 | In Stock | 1 | |
| 10mg | $62.00 | In Stock | 1 | |
| 20mg | $100.00 | In Stock | 1 | |
| 50mg | $193.00 | In Stock | 1 | |
| 100mg | $289.00 | In Stock | 1 |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citations
1 publicationsPublications from researchers using this productDescription
TIC10 isomer is the analogue of TIC10/ONC201[1]. The TIC10 isomer can be used as a model compound to analyze the active structure and optimize the production route of TIC10[2]. TIC10 isomer can be used as an internal reference to develop new nuclear magnetic resonance (NMR) methods for characterizing related compounds[3].
References:
[1] Greer Y E, Lipkowitz S. TIC10/ONC201: a bend in the road to clinical development[J]. Oncoscience, 2015, 2(2): 75.
[2] Jacob N T, Lockner J W, Kravchenko V V, et al. Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL[J]. Angewandte Chemie, 2014, 126(26): 6746-6749.
[3] Oguadinma P, Bilodeau F, LaPlante S R. NMR strategies to support medicinal chemistry workflows for primary structure determination[J]. Bioorganic & medicinal chemistry letters, 2017, 27(2): 242-247.
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
41276-02-2
Synonyms
ONC201 isomer
Chemical Name
7-benzyl-10-(2-methylbenzyl)-2,3,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(10H)-one
SMILES
O=C1C(CN(CC2=CC=CC=C2)CC3)=C3N(CC4=CC=CC=C4C)C5=NCCN15
Molecular Formula
C24H26N4O
Molecular Weight
386.49
Solubility
≥ 6.43mg/mL in DMSO with gentle warming
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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