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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

Products for  PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GC10576 Imeglimin

    EMD 387008

    Antidiabetic agent

     Imeglimin Chemical Structure
  3. GC10956 Imeglimin hydrochloride Antidiabetic agent Imeglimin hydrochloride Chemical Structure
  4. GC12975 Indirubin

    C.I. 73200, Couroupitine B, Indigopurpurin, NSC 105327

     A cyclin-dependent kinases and GSK-3β inhibitor Indirubin Chemical Structure
  5. GC12661 Indirubin-3'-oxime Indirubin-3'-oxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-oxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM. Indirubin-3'-oxime Chemical Structure
  6. GC36312 Indirubin-3'-monoxime-5-sulphonic acid Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively. Indirubin-3'-monoxime-5-sulphonic acid Chemical Structure
  7. GC36313 Indirubin-5-sulfonate Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β. Indirubin-5-sulfonate Chemical Structure
  8. GC10969 INK 128(MLN0128)

    INK128; INK-128

     INK 128 (MLN0128) (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase. INK 128(MLN0128) Chemical Structure
  9. GC12416 INK1117

    MLN1117,TAK-117;Serabelisib

     INK1117 (MLN1117) is a selective p110α inhibitor with an IC50 of 15 nM. INK1117 Chemical Structure
  10. GC69282 Insulin Detemir

    Insulin Detemir is an artificial insulin that helps control blood sugar levels. It works by activating the -cat and CREB signaling pathways, which depend on Akt and extracellular signal-regulated kinase (ERK), to promote Gcg expression and stimulate GLP-1 secretion. Insulin Detemir can be used in research for type 2 diabetes.

     Insulin Detemir Chemical Structure
  11. GC65559 INY-03-041 INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide (Cereblon ligand). INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively. INY-03-041 Chemical Structure
  12. GC73871 INY-05-040 INY-05-040 is a AKT degrader that can selectively and quickly degrade all three AKT isoforms. INY-05-040 Chemical Structure
  13. GC32794 Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively. Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride)) Chemical Structure
  14. GC10749 IPI-145 (INK1197)

    Duvelisib, INK1197

     IPI-145 (INK1197) (IPI-145) is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively. IPI-145 (INK1197) Chemical Structure
  15. GC31756 IPI-3063 IPI-3063 is a potent and selective PI3K p110δ inhibitor with an IC50 of 2.5?±?1.2 nM. IPI-3063 Chemical Structure
  16. GC19202 IPI549

    IPI-549

     IPI549 (IPI549) is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM. IPI549 shows >100-fold selectivity over other lipid and protein kinases. IPI549 Chemical Structure
  17. GC13795 Isobavachalcone

    Corylifolinin, IBC

     A chalcone and flavonoid with diverse biological activities Isobavachalcone Chemical Structure
  18. GC70377 Isoprocurcumenol Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol Chemical Structure
  19. GN10023 Isorhamnetin

    3'Omethyl Quercetin

     Isorhamnetin Chemical Structure
  20. GC32995 JNJ-47117096 hydrochloride (MELK-T1 hydrochloride)

    MELK-T1 hydrochloride

     JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM. JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) Chemical Structure
  21. GC34909 JR-AB2-011 A selective mTORC2 inhibitor JR-AB2-011 Chemical Structure
  22. GC33357 K-80003 (TX-803)

    TX-803

     K-80003 (TX-803) is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth. K-80003 (TX-803) Chemical Structure
  23. GC61993 Kaempferol 3-O-β-D-glucuronide

    Kaempferol 3-O-β-glucuronide

     Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide Chemical Structure
  24. GC48507 Kaempferol 3-O-galactoside

    Trifolin

     Kaempferol 3-O-galactoside (Trifolin) is a derivative of flavonoid, which is isolated from the aerial part of Consolida oliveriana. Kaempferol 3-O-galactoside Chemical Structure
  25. GC38209 Kahweol A natural diterpene with antiinflammatory and antiangiogenic properties Kahweol Chemical Structure
  26. GC63934 Karanjin Karanjin is a major active furanoflavonol constituent of Fordia cauliflora. Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis. Karanjin Chemical Structure
  27. GC32118 KDU691 An antimalarial compound KDU691 Chemical Structure
  28. GC38033 KDU731 KDU731, an orally active C. KDU731 Chemical Structure
  29. GC14182 Kenpaullone

    9Bromopaullone, NSC 664704

     CDK1/cyclin B and GSK-3β inhibitor Kenpaullone Chemical Structure
  30. GC15553 KP372-1 specific Akt inhibitor KP372-1 Chemical Structure
  31. GC73992 KTC1101 KTC1101 is an orally active pan-PI3K inhibitor. KTC1101 Chemical Structure
  32. GC14346 KU-0060648 Dual DNA-PK/PI3-K inhibitor, ATP-competitive KU-0060648 Chemical Structure
  33. GC15167 KU-0063794 MTORC1 and mTORC2 inhibitor KU-0063794 Chemical Structure
  34. GC68037 L-Leucine-1-13C,15N L-Leucine-1-13C,15N Chemical Structure
  35. GC68219 L-Leucine-13C L-Leucine-13C Chemical Structure
  36. GC63833 L-Leucine-15N L-Leucine-15N Chemical Structure
  37. GC66357 L-Leucine-d2 L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway. L-Leucine-d2 Chemical Structure
  38. GC64188 L-Leucine-d3 L-Leucine-d3 is a deuterated form of L-Leucine that is used for mass spectrometry (MS) quantification of proteins and as a tracer in metabolic studies. L-Leucine-d3 Chemical Structure
  39. GC10573 L803-mts Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3) L803-mts Chemical Structure
  40. GC36426 LAS191954 LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM. LAS191954 Chemical Structure
  41. GC19471 Leniolisib

    CDZ 173

    A potent and selective PI3Kδ inhibitor

     Leniolisib Chemical Structure
  42. GC71524 Leniolisib phosphate Leniolisib (CDZ173) phosphate is a potent and selective PI3Kδ inhibitor. Leniolisib phosphate Chemical Structure
  43. GC74094 Leniolisib-d5

    CDZ173-d5

     Leniolisib-d5 is a deuterated labeled Leniolisib. Leniolisib-d5 Chemical Structure
  44. GC69370 Leucine-13C6

    Leucine-13C6 is a 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA) that can activate the mTOR signaling pathway.

     Leucine-13C6 Chemical Structure
  45. GC36447 Licochalcone E Licochalcone E, a flavonoid compound isolated from Glycyrrhiza inflate, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation. Licochalcone E Chemical Structure
  46. GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin Chemical Structure
  47. GC16039 LJH685 RSK (p90 ribosomal S6 kinase) inhibitor LJH685 Chemical Structure
  48. GC16601 LJI308

    pan-RSK inhibitor

     LJI308 Chemical Structure
  49. GC30770 LM22B-10 An activator of TrkB and TrkC LM22B-10 Chemical Structure
  50. GC32510 Loureirin A Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. Loureirin A Chemical Structure
  51. GC50276 LTURM 36 PI 3-kinase δ inhibitor LTURM 36 Chemical Structure
  52. GC19227 LTURM34

    LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.

     LTURM34 Chemical Structure
  53. GC30884 LX2343 An inhibitor of BACE1 and PI3K LX2343 Chemical Structure
  54. GC50009 LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases LY 294002 hydrochloride Chemical Structure
  55. GC12045 LY 303511 An inhibitor of cell proliferation LY 303511 Chemical Structure
  56. GC17187 LY2090314

    LY 2090314;LY-2090314

     A potent and selective inhibitor of GSK3 LY2090314 Chemical Structure
  57. GC12089 LY2584702 LY2584702 is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM. LY2584702 Chemical Structure
  58. GC14371 LY3023414

    LY3023414

     LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. LY3023414 potently inhibits mTORC1/2 at low nanomolar concentrations. LY3023414 Chemical Structure
  59. GC73792 Lys(CO-C3-p-I-Ph)-O-tBu Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu Chemical Structure
  60. GC73791 Lys(CO-C3-p-I-Ph)-OMe Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe Chemical Structure
  61. GC39715 M2698

    MSC2363318A

     M2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity. M2698 Chemical Structure
  62. GC61029 Marein A glucoside chalcone with diverse biological activities Marein Chemical Structure
  63. GC70337 MARK-IN-4 MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM. MARK-IN-4 Chemical Structure
  64. GC73537 MARK4 inhibitor 2 MARK4 inhibitor 2 is an inhibitor of microtubule affinity-regulating kinase 4 (MARK4) with an Km of 6.3×10 7 and an IC50 of 0.82 μM. MARK4 inhibitor 2 Chemical Structure
  65. GC48707 MDK34597 MDK34597 (compound 35) is a potent PI3K p110α inhibitor with an pIC50 of 6.85. MDK34597 Chemical Structure
  66. GC25626 MELK-8a Dihydrochloride MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM. MELK-8a Dihydrochloride Chemical Structure
  67. GC32736 MELK-8a hydrochloride

    NVS-MELK8a

     MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM. MELK-8a hydrochloride Chemical Structure
  68. GC66065 MELK-IN-1 MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively. MELK-IN-1 Chemical Structure
  69. GC61045 Metformin D6 hydrochloride

    1,1-Dimethylbiguanide hydrochloride-d6

     An internal standard for the quantification of metformin Metformin D6 hydrochloride Chemical Structure
  70. GC17443 Metformin HCl

    1,1-Dimethylbiguanide hydrochloride

     Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin HCl Chemical Structure
  71. GC38815 Methyl cinnamate Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate Chemical Structure
  72. GC72005 Methyllucidone Methyllucidone is a neuroprotective agent and an antioxidant that can be isolated from Lindera erythrocarpa Makino. Methyllucidone Chemical Structure
  73. GC64402 MHY-1685 MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, provides opportunities to improve hCSC-based myocardial regeneration. MHY-1685 Chemical Structure
  74. GC13790 MHY1485 MHY1485 is a potent activator of mTOR, which inhibits autophagy and the fusion between autophagosomes and lysosomes. MHY1485 Chemical Structure
  75. GC10811 Miltefosine

    Hexadecylphosphocholine, HPC, NSC 605583

     PI3K/Akt inhibitor Miltefosine Chemical Structure
  76. GC25638 Miransertib (ARQ 092) HCl

    Miransertib

     Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors. Miransertib (ARQ 092) HCl Chemical Structure
  77. GC16304 MK-2206 dihydrochloride

    MK-2206,MK2206,MK 2206

     MK-2206 dihydrochloride is an orally active allosteric Akt inhibitor used in treatment of solid tumors. MK-2206 dihydrochloride Chemical Structure
  78. GC31361 MK-3903 MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM. MK-3903 Chemical Structure
  79. GC31470 MK8722 MK8722 is a potent and systemic pan-AMPK activator. MK8722 Chemical Structure
  80. GC65143 MKC-1

    Ro-31-7453

     MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family. MKC-1 Chemical Structure
  81. GC62109 MMV390048 MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 ?M). MMV390048 Chemical Structure
  82. GC66013 MOMIPP MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB). MOMIPP Chemical Structure
  83. GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway. MOTS-c Chemical Structure
  84. GC73358 MS15 TFA MS15 TFA is a potent and selective AKT PROTAC degrader. MS15 TFA Chemical Structure
  85. GC65466 MS170 MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively. MS170 Chemical Structure
  86. GC60258 MT 63-78 MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63-78 Chemical Structure
  87. GC64304 MTI-31

    LXI-15029

     MTI-31 is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 Chemical Structure
  88. GC65115 mTOR inhibitor-1 mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. mTOR inhibitor-1 Chemical Structure
  89. GC62339 mTOR inhibitor-8 mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells. mTOR inhibitor-8 Chemical Structure
  90. GC19256 MTX-211

    Mol 211

     MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases. MTX-211 Chemical Structure
  91. GC74012 MTX-531 MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 Chemical Structure
  92. GC65442 Musk ketone Musk ketone (MK) is a widely used artificial fragrance. Musk ketone Chemical Structure
  93. GC60262 N-Feruloyloctopamine N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases thephosphorylationlevels of Akt and p38MAPK. N-Feruloyloctopamine Chemical Structure
  94. GC31536 N-Oleoyl glycine

    A putative substrate for peptidyl glycine αamidating enzyme

     N-Oleoyl glycine Chemical Structure
  95. GC36714 Nemiralisib

    GSK2269557 (free base)

     Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9. Nemiralisib Chemical Structure
  96. GC72950 NEO214 NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram and perillyl alcohol. NEO214 Chemical Structure
  97. GC38567 Nepodin

    Musizin, NSC 365795

     A naphthol with diverse biological activities Nepodin Chemical Structure
  98. GC19843 Nimbolide

    NSC 309909

    Nimbolide is a triterpene derived from the leaves and flowers of Azadirachta indica L. Nimbolide inhibits NF- κ B induces tumor cell apoptosis. Nimbolide inhibited CDK4 / Cdk6 kinase activity. Nimbolide inhibits NF- κ B. Wnt, PI3K Akt, MAPK and JAK-STAT signaling pathways.

     Nimbolide Chemical Structure
  99. GC18089 Nordihydroguaiaretic acid

    NDGA, NSC 4291

     A non-selective LO inhibitor Nordihydroguaiaretic acid Chemical Structure
  100. GC11907 NSC 210902 NSC 210902 is a CK2 inhibitor, with an IC50 of 150 nM. NSC 210902 Chemical Structure
  101. GC33014 NSC781406 A dual inhibitor of PI3K and mTOR NSC781406 Chemical Structure

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