PI3K/Akt/mTOR Signaling

BX795 is an inhibitor of 3-phosphoinositide-dependent protein kinase 1 (PDK1), with an IC 50 value of 11nM.

A potent inhibitor of Akt1 and Akt2

third-generation mTOR inhibitor

TCS 2002 (Compound 9b) is a highly selective, orally bioavailable and potent GSK-3β inhibitor with the IC50 of 35 nM.

SC 79 is a specific, blood-brain barrier-permeable Akt agonist.

Akt signaling inhibitor

GSK621 is a specific AMP-activated protein kinase (AMPK) agonist. GSK621 can induce autophagy and apoptosis by activating the AMPK signaling pathway.

AZD5363 is a selective inhibitor of the protein kinases AKT1, AKT2, and AKT3, with IC₅₀ values of 3, 7, and 7nM, respectively. AZD5363 targets the PI3K/AKT/mTOR signaling pathway and has demonstrated anti-tumor activity and potential therapeutic applications in various cancers.

NSC 210902 is a CK2 inhibitor, with an IC50 of 150 nM.

PI3Kγ inhibitor

An inhibitor of class I PI3K isoforms

Akt inhibitor

MTOR inhibitor

An inhibitor of cell proliferation

LY2584702 is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.

Akt and PDPK1 inhibitor

CUDC-907 is a dual inhibitor of PI3K and HDAC with IC 50 values of 19, 54, and 39nM for PI3Kα, PI3Kβ, and PI3Kδ, respectively.

novel AMPK allosteric activator

TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC 50 of 0.15μM for rat liver CK2.

Akt1/2/3 and p70S6K/PKA inhibitor

AMPK activator

PI3K/mTOR inhibitor

Wortmannin is a potent, selective, and irreversible PI3K inhibitor with an IC 50 value of 4.2nM.

SAMS Peptide peptide is a specific substrate for the AMP-activated protein kinase (AMPK).