PI3K/Akt/mTOR Signaling
- Akt(129)
- AMPK(75)
- CK2(11)
- DNA-PK(25)
- GSK-3(76)
- MELK(7)
- mTOR(118)
- PI3K(227)
- PI4K(15)
- PDK-1(18)
- PIKfyve(4)
- PKB(1)
- S6 Kinase(12)
Products for PI3K/Akt/mTOR Signaling
- Cat.No. Product Name Information
- GC36426 LAS191954 LAS191954 is a potent, selective and orally active PI3Kδ inhibitor for inflammatory diseases treatment, with an IC50 of 2.6 nM.
-
GC19471
Leniolisib
A potent and selective PI3Kδ inhibitor
- GC36447 Licochalcone E Licochalcone E, a flavonoid compound isolated from Glycyrrhiza inflate, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation.
- GC36456 Licoricidin Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities.
- GC16039 LJH685 RSK (p90 ribosomal S6 kinase) inhibitor
-
GC16601
LJI308
pan-RSK inhibitor
- GC30770 LM22B-10 An activator of TrkB and TrkC
- GC32510 Loureirin A Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.
- GC50276 LTURM 36 PI 3-kinase δ inhibitor
-
GC19227
LTURM34
LTURM34 is a specific DNA-PK inhibitor with an IC50 of 0.034 uM.
- GC30884 LX2343 An inhibitor of BACE1 and PI3K
- GC12045 LY 303511 An inhibitor of cell proliferation
- GC17187 LY2090314 A potent and selective inhibitor of GSK3
- GC12089 LY2584702 LY2584702 is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.
- GC14371 LY3023414 LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. LY3023414 potently inhibits mTORC1/2 at low nanomolar concentrations.
- GC61029 Marein A glucoside chalcone with diverse biological activities
- GC48707 MDK34597 MDK34597 (compound 35) is a potent PI3K p110α inhibitor with an pIC50 of 6.85.
- GC25626 MELK-8a Dihydrochloride MELK-8a Dihydrochloride is a novel inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM.
- GC32736 MELK-8a hydrochloride MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor with an IC50 of 2 nM.
- GC66065 MELK-IN-1 MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 and a Ki of 3 nM and 0.39 nM, respectively.
- GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin
- GC17443 Metformin HCl Metformin HCl (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research.
- GC38815 Methyl cinnamate Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound.
- GC64402 MHY-1685 MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, provides opportunities to improve hCSC-based myocardial regeneration.
- GC13790 MHY1485 MHY1485 is a potent activator of mTOR, which inhibits autophagy and the fusion between autophagosomes and lysosomes.
- GC10811 Miltefosine PI3K/Akt inhibitor
- GC25638 Miransertib (ARQ 092) HCl Miransertib (ARQ 092) HCl is a novel, orally bioavailable and selective AKT pathway inhibitor exhibiting a manageable safety profile among patients with advanced solid tumors.
-
GC16304
MK-2206 dihydrochloride
An allosteric Akt inhibitor
- GC31361 MK-3903 MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
- GC31470 MK8722 MK8722 is a potent and systemic pan-AMPK activator.
- GC65143 MKC-1 MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family.
- GC49440 ML-9 A PKB/Akt inhibitor
- GC62109 MMV390048 MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 ?M).
- GC66013 MOMIPP MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).
- GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.
- GC65466 MS170 MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively.
- GC60258 MT 63-78 MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects.
- GC64304 MTI-31 MTI-31 is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2.
- GC65115 mTOR inhibitor-1 mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.
- GC62339 mTOR inhibitor-8 mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.
- GC19256 MTX-211 MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases.
- GC65442 Musk ketone Musk ketone (MK) is a widely used artificial fragrance.
- GC60262 N-Feruloyloctopamine N-Feruloyloctopamine is an antioxidant constituent. N-Feruloyloctopamine significantly decreases thephosphorylationlevels of Akt and p38MAPK.
-
GC31536
N-Oleoyl glycine
A putative substrate for peptidyl glycine αamidating enzyme
- GC36714 Nemiralisib Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9.
- GC38567 Nepodin A naphthol with diverse biological activities
- GC18089 Nordihydroguaiaretic acid A non-selective LO inhibitor
- GC11907 NSC 210902 NSC 210902 is a CK2 inhibitor, with an IC50 of 150 nM.
- GC33014 NSC781406 A dual inhibitor of PI3K and mTOR
- GC12332 NU 7026 DNPK inhibitor,ATP-competitive and potent
- GC11251 NU7441 (KU-57788) NU7441 (KU-57788) (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. NU7441 (KU-57788) is an NHEJ pathway inhibitor. NU7441 (KU-57788) also inhibits PI3K and mTOR with IC50s of 5.0 and 1.7 μM, respectively.
- GC63121 NV-5138 NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2.
- GC63122 NV-5138 hydrochloride NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2.
- GC13725 NVP-BAG956 A dual PDK1 and class I PI3K inhibitor
- GC16145 NVP-BGT226 BGT226 (NVP-NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells.
- GC14504 NVP-BKM120 Hydrochloride An inhibitor of class I PI3K isoforms
- GC36786 NVP-QAV-572 NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM.
- GC62141 NVS-PI3-4 NVS-PI3-4 is a specific PI3Kγ inhibitor.
- GC19269 O-304 O-304 is a small molecule AMPK activator.
- GC36807 ON 146040 ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).
-
GN10692
Oridonin
A diterpenoid with anti-inflammatory and anticancer properties
- GN10732 Oroxin B
- GC14071 OSI-027 MTORC1/ mTORC2 inhibitor
- GC15742 OSU-03012 (AR-12) Potent PDK1 inhibitor
- GC10201 OTSSP167 MELK inhibitor
- GC12155 OTSSP167 hydrochloride MELK inhibitor,highly potent and selective
- GC15740 OXA-01 mTORC1 and mTORC2 inhibitor
- GC36832 P110δ-IN-1 P110δ-IN-1 is a potent and selective inhibitor of P110δ extracted from patent WO 2014055647 A1, with an IC50 of 8.4 nM.
- GN10752 Pachymic acid
- GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid) Palmitelaidic Acid (9-trans-Hexadecenoic acid) (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid.
-
GC12773
Palomid 529
PI3K/Akt/mTOR inhibitor
- GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.
- GC32916 Parsaclisib (INCB050465) Parsaclisib (INCB050465) (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib (INCB050465) shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib (INCB050465) can be used for the research of relapsed or refractory B-cell malignancies.
- GC62593 Parsaclisib hydrochloride Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies.
- GC12866 PDK1 inhibitor
- GC66474 PDK1-IN-RS2 PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1.
- GC44587 PDMP (hydrochloride) PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase.
- GC15680 Perifosine Akt inhibitor
- GC16417 PF-04691502 PI3K/mTOR (FRAP) inhibitor
- GC63446 PF-04802367 PF-04802367 (PF-367) is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.
- GC19283 PF-04979064 PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.
- GC15653 PF-05212384 (PKI-587) PF-05212384 (PKI-587) (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PF-05212384 (PKI-587) is equally effective in both complexes of mTOR, mTORC1 and mTORC2.
- GC19286 PF-06409577 PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM.
- GC66002 PF-06685249 PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research.
- GC62556 PF-06843195 PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy.
- GC62660 PF-07104091 PF-07104091 is a CDK2/cyclin E1 inhibitor, a selective ATP-site inhibitor targeting the cyclin-bound activated state of the kinase [1].
-
GC62661
PF-07104091 hydrate
PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively.
- GC10689 PF-4708671 PF-4708671, is a novel cell-permeable inhibitor of S6K1, specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM.
- GC12375 PF-4989216 Selective oral PI3K inhibitor
- GC32892 PF-AKT400 (AKT protein kinase inhibitor) PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM).
- GC38170 Phellodendrine
- GC10461 Phenformin HCl Phenformin HCl is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
- GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases.
- GC12094 PHT-427 Akt and PDPK1 inhibitor
-
GC10386
PI 828
PI 3-Kinase inhibitor
- GC11165 PI-103 Class I PI3K, mTOR and DNA-PK inhibitor
- GC16379 PI-103 Hydrochloride A potent, cell-permeable PI3K inhibitor
- GC39155 PI-273 PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
- GC15310 PI-3065 P110δkinase inhibitor
- GC38578 PI-828 A PI3K inhibitor