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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

Products for  PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GC12332 NU 7026

    DNAPK Inhibitor II, LY293646

     DNPK inhibitor,ATP-competitive and potent NU 7026 Chemical Structure
  3. GC11251 NU7441 (KU-57788)

    KU 57788; NU-7441;KU57788;NU7441;NU 7441

     NU7441 (KU-57788) is a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 of 13nM. NU7441 also inhibits phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with IC50 of 5.0 and 1.7μM, respectively. NU7441 (KU-57788) Chemical Structure
  4. GC63121 NV-5138 NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 Chemical Structure
  5. GC63122 NV-5138 hydrochloride NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride Chemical Structure
  6. GC13725 NVP-BAG956

    BAG956

     A dual PDK1 and class I PI3K inhibitor NVP-BAG956 Chemical Structure
  7. GC44475 NVP-BEZ235 (hydrochloride)

    Dactolisib

     NVP-BEZ235 is a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. NVP-BEZ235 (hydrochloride) Chemical Structure
  8. GC16145 NVP-BGT226

    NVP-BGT226 maleate

     BGT226 (NVP-NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells. NVP-BGT226 Chemical Structure
  9. GC14504 NVP-BKM120 Hydrochloride An inhibitor of class I PI3K isoforms NVP-BKM120 Hydrochloride Chemical Structure
  10. GC36786 NVP-QAV-572 NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM. NVP-QAV-572 Chemical Structure
  11. GC62141 NVS-PI3-4 NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 Chemical Structure
  12. GC19269 O-304 O-304 is a small molecule AMPK activator. O-304 Chemical Structure
  13. GC36807 ON 146040 ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM). ON 146040 Chemical Structure
  14. GN10692 Oridonin

    NSC 250682

     Oridonin is an inhibitor of protein kinase B (AKT; PKB), with IC50 values of 8.4 and 8.9μM for AKT1 and AKT2 respectively. Oridonin Chemical Structure
  15. GN10732 Oroxin B Oroxin B Chemical Structure
  16. GC14071 OSI-027 MTORC1/ mTORC2 inhibitor OSI-027 Chemical Structure
  17. GC15742 OSU-03012 (AR-12) Potent PDK1 inhibitor OSU-03012 (AR-12) Chemical Structure
  18. GC10201 OTSSP167 MELK inhibitor OTSSP167 Chemical Structure
  19. GC12155 OTSSP167 hydrochloride MELK inhibitor,highly potent and selective OTSSP167 hydrochloride Chemical Structure
  20. GC15740 OXA-01 mTORC1 and mTORC2 inhibitor OXA-01 Chemical Structure
  21. GC70464 P-2281 P-2281 is a mTOR inhibitor with anticancer and anti-inflammatory efficacies. P-2281 Chemical Structure
  22. GC36832 P110δ-IN-1 P110δ-IN-1 is a potent and selective inhibitor of P110δ extracted from patent WO 2014055647 A1, with an IC50 of 8.4 nM. P110δ-IN-1 Chemical Structure
  23. GN10752 Pachymic acid

    3-O-Acetyltumulosic Acid, NSC 244427

     Pachymic acid Chemical Structure
  24. GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid)

    C16:1(9E), 9-trans-Hexadecenoic Acid

     Palmitelaidic Acid (9-trans-Hexadecenoic acid) (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitelaidic Acid (9-trans-Hexadecenoic acid) Chemical Structure
  25. GC12773 Palomid 529

    P529, RES-529, SG 00529

    PI3K/Akt/mTOR inhibitor

     Palomid 529 Chemical Structure
  26. GC36855 Paris saponin VII Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia. Paris saponin VII Chemical Structure
  27. GC32916 Parsaclisib (INCB050465)

    INCB050465

     Parsaclisib (INCB050465) (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib (INCB050465) shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib (INCB050465) can be used for the research of relapsed or refractory B-cell malignancies. Parsaclisib (INCB050465) Chemical Structure
  28. GC62593 Parsaclisib hydrochloride

    INCB050465 hydrochloride

     Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies. Parsaclisib hydrochloride Chemical Structure
  29. GC12866 PDK1 inhibitor PDK1 inhibitor Chemical Structure
  30. GC72885 PDK1-IN-2 PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1). PDK1-IN-2 Chemical Structure
  31. GC66474 PDK1-IN-RS2 PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 Chemical Structure
  32. GC44587 PDMP (hydrochloride)

    DL-erythro/threo-PDMP

     PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase. PDMP (hydrochloride) Chemical Structure
  33. GC15680 Perifosine

    NSC639966;KRX-0401;KRX0401;D-21266;D21266

    Perifosine is an inhibitor of Akt .

     Perifosine Chemical Structure
  34. GC16417 PF-04691502 PI3K/mTOR (FRAP) inhibitor PF-04691502 Chemical Structure
  35. GC63446 PF-04802367

    PF-367

     PF-04802367 (PF-367) is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367 Chemical Structure
  36. GC19283 PF-04979064 PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively. PF-04979064 Chemical Structure
  37. GC15653 PF-05212384 (PKI-587)

    PK-1587, PKI-587

     PF-05212384 (PKI-587) (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. PF-05212384 (PKI-587) is equally effective in both complexes of mTOR, mTORC1 and mTORC2. PF-05212384 (PKI-587) Chemical Structure
  38. GC19286 PF-06409577 PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM. PF-06409577 Chemical Structure
  39. GC66002 PF-06685249

    PF-249

     PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research. PF-06685249 Chemical Structure
  40. GC62556 PF-06843195 PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy. PF-06843195 Chemical Structure
  41. GC62660 PF-07104091 PF-07104091 is a CDK2/cyclin E1 inhibitor, a selective ATP-site inhibitor targeting the cyclin-bound activated state of the kinase PF-07104091 Chemical Structure
  42. GC62661 PF-07104091 hydrate PF-07104091 hydrate is a potent and selective inhibitor of CDK2/E1 and GSK3β with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has antitumor activity against cyclin E1-amplified cancers and is commonly used to treat HR+/HER2- breast cancer and ovarian cancer PF-07104091 hydrate Chemical Structure
  43. GC10689 PF-4708671 PF-4708671, is a novel cell-permeable inhibitor of S6K1, specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 Chemical Structure
  44. GC12375 PF-4989216 Selective oral PI3K inhibitor PF-4989216 Chemical Structure
  45. GC70439 PF-739 PF-739 is an orally active and non-selective activator of AMPK. PF-739 Chemical Structure
  46. GC32892 PF-AKT400 (AKT protein kinase inhibitor) PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM). PF-AKT400 (AKT protein kinase inhibitor) Chemical Structure
  47. GC73268 PH14 PH14 is a dual PI3K/HDAC inhibitor with IC50 values of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively. PH14 Chemical Structure
  48. GC38170 Phellodendrine Phellodendrine Chemical Structure
  49. GC10461 Phenformin HCl Phenformin HCl is an anti-diabetic drug from the biguanide class, can activate AMPK activity. Phenformin HCl Chemical Structure
  50. GC19921 Phenylarsine Oxide

    Arsenoso-Benzen;FenylArsinoxid;Oxophenyl-Arsin;Oxophenylarsine;Pao;Phenyl Arsene Oxide;Phenyl ARSENOxide;PhenylARSINE Oxide

     Phenylarsine Oxide Chemical Structure
  51. GC65375 Phospho-Glycogen Synthase Peptide-2(substrate) TFA Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate?for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases. Phospho-Glycogen Synthase Peptide-2(substrate) TFA Chemical Structure
  52. GC12094 PHT-427

    Akt Inhibitor XIV

     Akt and PDPK1 inhibitor PHT-427 Chemical Structure
  53. GC10386 PI 828

    PI 3-Kinase inhibitor

     PI 828 Chemical Structure
  54. GC11165 PI-103 Class I PI3K, mTOR and DNA-PK inhibitor PI-103 Chemical Structure
  55. GC16379 PI-103 Hydrochloride

    PI 103 hydrochloride;PI103 hydrochloride

     A potent, cell-permeable PI3K inhibitor PI-103 Hydrochloride Chemical Structure
  56. GC39155 PI-273 PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis. PI-273 Chemical Structure
  57. GC15310 PI-3065 P110δkinase inhibitor PI-3065 Chemical Structure
  58. GC38578 PI-828 A PI3K inhibitor PI-828 Chemical Structure
  59. GC44641 PI3-Kinase α Inhibitor 2

    PI3Kα Inhibitor 2, Phosphatidylinositol 3Kinase α Inhibitor 2

     Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3-Kinase α Inhibitor 2 Chemical Structure
  60. GC44642 PI3-Kinase α Inhibitor 2 (hydrochloride)

    Phosphatidylinositol 3-Kinase α Inhibitor 2, PI3Kα Inhibitor 2

     A PI3K p110α inhibitor PI3-Kinase α Inhibitor 2 (hydrochloride) Chemical Structure
  61. GC62521 PI3Kα-IN-4 PI3Kα-IN-4 is a potent, selective and orally active inhibitor of PI3Kα, with an IC50 of 1.8 nM. PI3Kα-IN-4 has antitumor activity. PI3Kα-IN-4 Chemical Structure
  62. GC73313 PI3Kα-IN-9 PI3Kα-IN-9 (compound 27) is a selective, long-acting and oral active PI3Kα inhibitor with IC50 values of 4.4, 128, 146 and 153 nM for PI3Kα, PI3Kγ, PI3Kδ and PI3Kβ, respectively. PI3Kα-IN-9 Chemical Structure
  63. GC36909 PI3Kα/mTOR-IN-1 PI3Kα/mTOR-IN-1 is a potent PI3Kα/mTOR dual inhibitor, with an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell free assay , respectively. PI3Kα/mTOR-IN-1 Chemical Structure
  64. GC36910 PI3Kγ inhibitor 1 PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of <100 nM. PI3Kγ inhibitor 1 Chemical Structure
  65. GC36911 PI3kδ inhibitor 1 PI3kδ inhibitor 1 is a potent and selective PI3Kδ inhibitor with an IC50 of 3.8 nM. PI3kδ inhibitor 1 Chemical Structure
  66. GC65199 PI3Kδ-IN-1 PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM. PI3Kδ-IN-1 Chemical Structure
  67. GC72806 PI3Kδ-IN-15 PI3Kδ-IN-15 (compound 6b) is a selective PI3Kδ inhibitor with an IC50 of 0.5 nM for p110δ. PI3Kδ-IN-15 Chemical Structure
  68. GC73555 PI3Kδ-IN-16 PI3Kδ-IN-16 is a potent and selective inhibitor of PI3Kδ. PI3Kδ-IN-16 Chemical Structure
  69. GC31751 PI3Kδ-IN-2

    YY-20394

     PI3Kδ-IN-2 (YY-20394) is a potent, orally bioavailable and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1, compound 10; has an IC50 of 6.4 nM. PI3Kδ-IN-2 Chemical Structure
  70. GC36907 PI3K-IN-2 PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC50=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC50=13/190 nM, respectively). PI3K-IN-2 Chemical Structure
  71. GC69707 PI3K-IN-30

    PI3K-IN-30 (compound 6d) is an effective PI3K inhibitor with IC50 values of 5.1 nM, 136 nM, 30.7 nM and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ respectively.

     PI3K-IN-30 Chemical Structure
  72. GC69708 PI3K-IN-31

    PI3K-IN-31 (Compound 6b) is an effective PI3K inhibitor with IC50 values of 3.7 nM, 74 nM, 14.6 nM and 9.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ respectively. It has anti-cancer properties.

     PI3K-IN-31 Chemical Structure
  73. GC67954 PI3K-IN-36 PI3K-IN-36 Chemical Structure
  74. GC36908 PI3K-IN-6 PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors. PI3K-IN-6 Chemical Structure
  75. GC69706 PI3K/AKT-IN-1

    PI3K/AKT-IN-1 is an effective dual inhibitor of PI3K/AKT (with IC50 values of 6.99 μM, 4.01 μM, and 3.36 μM for PI3Kα, PI3Kδ, and AKT, respectively). It has anti-cancer activity by inhibiting the PI3K/AKT pathway and inducing caspase 3-dependent apoptosis.

     PI3K/AKT-IN-1 Chemical Structure
  76. GC66463 PI3K/Akt/mTOR-IN-2 PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis. PI3K/Akt/mTOR-IN-2 Chemical Structure
  77. GC36905 PI3K/HDAC-IN-1 PI3K/HDAC-IN-1 is a potent dual inhibitor of PI3K/HDAC, potently inhibits PI3Kδ and HDAC1 with IC50s of 8.1 nM and 1.4 nM, respectively. PI3K/HDAC-IN-1 Chemical Structure
  78. GC69709 PI3K/mTOR Inhibitor-11

    PI3K/mTOR Inhibitor-11 is an orally active inhibitor of PI3K/mTOR (with IC50 values of 3.5, 4.6, and 21.3 nM for PI3Kα, PI3Kδ, and mTOR, respectively). It regulates the PI3K/AKT/mTOR signaling pathway by inhibiting the phosphorylation of AKT and S6 protein. PI3K/mTOR Inhibitor-11 can be used in cancer research.

     PI3K/mTOR Inhibitor-11 Chemical Structure
  79. GC69710 PI3K/mTOR Inhibitor-13 sodium

    PI3K/mTOR Inhibitor-13 sodium is an orally active dual inhibitor of phosphoinositide 3-kinase (PI3K) and mTOR kinase. PI3K/mTOR Inhibitor-13 sodium has potential applications in sexual disorders, solid tumors, and idiopathic pulmonary fibrosis (IPF).

     PI3K/mTOR Inhibitor-13 sodium Chemical Structure
  80. GC66447 PI3K/mTOR Inhibitor-4 PI3K/mTOR Inhibitor-4 is an orally active pan-class I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 has enzymatic inhibition activity for PI3Kα, PI3Kγ, PI3Kδ and mTOR with IC50 values of 0.63 nM, 22 nM, 9.2 nM and 13.85 nM, respectively. PI3K/mTOR Inhibitor-4 can be used for the research of cancer. PI3K/mTOR Inhibitor-4 Chemical Structure
  81. GC36906 PI3Kdelta inhibitor 1 PI3Kdelta inhibitor 1 (Compound 5d) is a potent, selective and orally available PI3Kδ inhibitor with an IC50 of 1.3 nM. PI3Kdelta inhibitor 1 Chemical Structure
  82. GC72785 PI4K-IN-1 PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 Chemical Structure
  83. GC15508 PI4KIII beta inhibitor 3

    PI4KIII beta inhibitor 3

     PI4KIII beta inhibitor 3 Chemical Structure
  84. GC30777 PI4KIIIbeta-IN-10 PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM. PI4KIIIbeta-IN-10 Chemical Structure
  85. GC32847 PI4KIIIbeta-IN-9 PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively. PI4KIIIbeta-IN-9 Chemical Structure
  86. GC69991 Pifusertib hydrochloride

    TAS-117 hydrochloride

    Pifusertib (TAS-117) hydrochloride is an effective, selective, and orally active isoform Akt inhibitor (with IC50 values of 4.8, 1.6, and 44 nM for Akt1, 2, and 3 respectively). Pifusertib hydrochloride stimulates anti-myeloma activity and enhances lethal endoplasmic reticulum stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy in cells.

     Pifusertib hydrochloride Chemical Structure
  87. GC62340 PIK-108 PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor. PIK-108 Chemical Structure
  88. GC15982 PIK-293 PI3K inhibitor PIK-293 Chemical Structure
  89. GC13612 PIK-294 highly selective p110δ inhibitor PIK-294 Chemical Structure
  90. GC16904 PIK-75 PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis. PIK-75 Chemical Structure
  91. GC17199 PIK-90

    PIK85

     PI3K inhibitor,potent selective PIK-90 Chemical Structure
  92. GC13089 PIK-93 PI3Kγ/PI4KIIIβ/PI3Kα inhibitor PIK-93 Chemical Structure
  93. GC14679 PIK-III

    Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2

     PIK-III is a potent and selective inhibitor of VPS34 with an IC50 of 18 nM. PIK-III Chemical Structure
  94. GC73606 PIK5-12d PIK5-12d is a PROTAC PIKfyve degrader (DC50: 1.48 nM). PIK5-12d Chemical Structure
  95. GC69711 PIKfyve-IN-1

    PIKfyve-IN-1 is an efficient and cell-active chemical probe that can inhibit phosphoinositide 3-phosphate 5-kinase (PIKfyve) with an IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the study of PIKfyve in virology.

     PIKfyve-IN-1 Chemical Structure
  96. GC74025 PIKfyve-IN-3 PIKfyve-IN-3 (compound L22) has a remarkable interaction with PIKfyve kinase with a Kd value of 0.47 nM. PIKfyve-IN-3 Chemical Structure
  97. GC36917 Pilaralisib

    Pilaralisib, SAR245408

     A class I PI3K inhibitor Pilaralisib Chemical Structure
  98. GC11690 PIT 1 Akt signaling inhibitor PIT 1 Chemical Structure
  99. GC71378 PITCOIN4 PITCOIN4 is a highly selective Class II Alpha PI3K-C2α inhibitor. PITCOIN4 Chemical Structure
  100. GC69714 PKD-IN-1 dihydrochloride

    PKD-IN-1 dihydrochloride (compound 32) is an aminoethylaminobenzyl (AEAA) compound that can be used as a PKD-1 inhibitor. PKD-IN-1 can be used in research on diseases mediated by protein kinase D (PKD).

     PKD-IN-1 dihydrochloride Chemical Structure
  101. GC62140 PKI-179 PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo. PKI-179 Chemical Structure

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