PI3K/Akt/mTOR Signaling

SB 216763 stands out as a powerful, selective, and ATP-competitive inhibitor of GSK-3, effectively targeting both GSK-3α and GSK-3β with an impressive IC 50 of 34.3 nM [1-3] .

AICAR (also called acadesine) is a purine nucleoside.

Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3)

A CK2 inhibitor

MTOR inhibitor,potent,ATP-competitive and cell-permeable

3-Methyladenine is a PI3K inhibitor with IC 50 values of 25μM and 60μM for Vps34 and PtdIns3Kγ, respectively.

Bikinin is a non-steroidal, ATP-competitive inhibitor of plant GSK-3 (glycogen synthase kinase 3)/Shaggy-like kinases.

DNA-PK and mTOR inhibitor

inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinases

Acalisib (GS-9820) is a potent and selective PI3Kδ inhibitor with an IC50 of 12.7 nM.

A potent and orally bioavailable pan-Akt inhibitor

Dual inhibitor of tyrosine and phosphoinositide kinases

PI3K and mTOR inhibitor,potent and reversible

PI-103 is a potent cell-permeable multi-target inhibitor that primarily acts on the PI3K and mTOR signaling pathways.

GDC-0980 (RG7422) (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I PI3 kinase and mTOR kinase (TORC1/2) inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ, and with aKiof 17 nM for mTOR.

AMPK activator is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, AMPK activator inhibits cell growth.

GDC-0068 (RG7440) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC 50 values of 5, 18, 8nM for Akt1, Akt2, and Akt3, respectively.

A-769662 is an activator of AMP-activated protein kinase, which has an EC 50 value of 0.8μM.

PI3Kα and PI3Kδ inhibitor

CX-4945 sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.

SAR405 is a highly selective, ATP-competitive class III phosphoinositide 3-kinase (PIK3C3/Vps34) inhibitor with an IC 50 value of 1.2nM.

Scrambled control peptide for use with TCS 183