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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling

Products for  PI3K/Akt/mTOR Signaling

  1. Cat.No. Product Name Information
  2. GN10583 Dihydromyricetin

    (+)-Dihydromyricetin

     Dihydromyricetin is a natural flavanonol isolated from A. grossedentata and H. dulcis that has antioxidant, antiproliferative, anti-apoptotic, and anti-alcohol intoxication properties. Dihydromyricetin Chemical Structure
  3. GC60782 Disitertide TFA

    P144 TFA

     Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide (P144) TFA is also a PI3K inhibitor and an apoptosis inducer. Disitertide TFA Chemical Structure
  4. GC17837 DMAT

    Casein Kinase II Inhibitor II, 2-Dimethylamino-4,5,6,7-tetrabromobenzimidazole

     A cell-permeable inhibitor of CK2 DMAT Chemical Structure
  5. GC40561 DNA-PK Inhibitor IV DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 400 nM for the DNA-PK-dependent phosphorylation of a p53 peptide substrate. DNA-PK Inhibitor IV Chemical Structure
  6. GC74026 DNA-PK-IN-12 DNA-PK-IN-12 (compound 31t) is an oral active DNA-PK inhibitor with the IC50 of 0.1 nM. DNA-PK-IN-12 Chemical Structure
  7. GC17243 Dorsomorphin (Compound C)

    Compound C

     Dorsomorphin (Compound C) is an agent that used as a cell-permeable AMPK inhibitor. Dorsomorphin (Compound C) Chemical Structure
  8. GC12560 Dorsomorphin (Compound C) 2HCl

    BML-275 2HCl,Compound C 2HCl

     IC50: Dorsomorphin inhibited BMP4-induced phosphorylation of BMP-responsive SMADs in a dose-dependent manner (half maximal inhibitory concentration (IC50) =0.47 mM). Dorsomorphin (Compound C) 2HCl Chemical Structure
  9. GC17567 Doxorubicin (Adriamycin) HCl

    DOX

     Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin (Adriamycin) HCl Chemical Structure
  10. GC62495 DS-7423 DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity. DS-7423 Chemical Structure
  11. GC33162 Duvelisib R enantiomer (IPI-145 R enantiomer)

    IPI-145 R enantiomer; INK1197 R enantiomer

     Duvelisib R enantiomer is a PI3K inhibitor, which is the less active enantiomer of Duvelisib. Duvelisib R enantiomer (IPI-145 R enantiomer) Chemical Structure
  12. GC39377 EB-3D EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity. EB-3D Chemical Structure
  13. GC43585 eCF309 eCF309 is an ATP-competitive inhibitor of mTOR (IC50 = 15 nM in vitro and in cells) with >65-fold selectivity over other kinases, including PI3Ks. eCF309 Chemical Structure
  14. GC38330 EHT 5372 EHT 5372 Chemical Structure
  15. GC38694 Erucic acid

    cis-13-Docosenoate, (Z)-Erucic Acid

     A 22carbon monounsaturated fatty acid Erucic acid Chemical Structure
  16. GC38236 Esculetin

    Aesculetin, Cichorigenin, 6,7-Dihydroxycoumarin, NSC 26427

     A coumarin with diverse actions Esculetin Chemical Structure
  17. GC50072 ETP 45658 Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR ETP 45658 Chemical Structure
  18. GC19145 ETP-46321 ETP-46321 is a potent and orally bioavailable PI3Kα and PI3Kδ inhibitor with Kiapps of 2.3 and 14.2 nM, respectively. ETP-46321 Chemical Structure
  19. GC10196 ETP-46464

    ATM Inhibitor III, ATR Inhibitor III

     ATR inhibitor,potent and selective ETP-46464 Chemical Structure
  20. GC38422 Euphorbiasteroid A tricyclic diterpene Euphorbiasteroid Chemical Structure
  21. GC38392 Euscaphic acid Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM. Euscaphic acid induces apoptosis. Euscaphic acid Chemical Structure
  22. GC13601 Everolimus (RAD001)

    RAD001

     Everolimus (RAD001) is an orally active derivative of rapamycin that inhibits the Ser/Thr kinase, mTOR (mammalian target of rapamycin). Everolimus (RAD001) Chemical Structure
  23. GC47328 Everolimus-d4

    RAD001-d4; SDZ-RAD-d4

     An internal standard for the quantification of everolimus Everolimus-d4 Chemical Structure
  24. GC31411 EX229

    AMPK Activator 991

     A potent and allosteric activator of AMPK EX229 Chemical Structure
  25. GC62973 FD223 FD223 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. FD223 displays high potency (IC50=1 nM) and good selectivity over other isoforms (IC50s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML. FD223 Chemical Structure
  26. GC13466 Flufenamic acid

    CI-440, FFA, Fluphenamic Acid, NSC 82699, NSC 219007

    TRPC activator

     Flufenamic acid Chemical Structure
  27. GC14125 FMK

    fluoromethylketone-pyrrolopyrimidine scaffold

     An inhibitor of RSK2 FMK Chemical Structure
  28. GC71941 Foenumoside B Foenumoside B is a triterpene saponin isolated from Lysimachia foenum-graecum. Foenumoside B Chemical Structure
  29. GC17984 FPA 124

    Akt Inhibitor XI

    Akt/PKB inhibitor

     FPA 124 Chemical Structure
  30. GC38551 FPA-124 FPA-124 Chemical Structure
  31. GC17457 FRATide

    GSK-3 inhibitor

     FRATide Chemical Structure
  32. GC33355 FT-1518 FT-1518 is a new generation selective, potent and oral bioavailable mTORC1 and mTORC2 inhibitor, and exhibits antitumor activity. FT-1518 Chemical Structure
  33. GC61855 Galegine hydrochloride

    Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice.

     Galegine hydrochloride Chemical Structure
  34. GC17967 GDC-0032

    Taselisib

     GDC-0032 (GDC-0032) is a potent PI3K inhibitor targets PIK3CA mutations, with Kis of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively. GDC-0032 Chemical Structure
  35. GC11214 GDC-0068 (RG7440)

    Ipatasertib, RG-7440

     GDC-0068 (RG7440, Ipatasertib) is a novel highly selective ATP-competitive pan-Akt inhibitor that inhibits all three isoforms of Akt1, Akt2, and Akt3 at an IC50 of 5,18,8 nM, respectively. GDC-0068 (RG7440) Chemical Structure
  36. GC32710 GDC-0077 (RG6114)

    GDC-0077; RG6114

     GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα. GDC-0077 (RG6114) Chemical Structure
  37. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable GDC-0084 Chemical Structure
  38. GC19161 GDC-0326 GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM. GDC-0326 Chemical Structure
  39. GC12021 GDC-0349 MTOR inhibitor GDC-0349 Chemical Structure
  40. GC16154 GDC-0941 dimethanesulfonate

    GDC-0941 (2 MeSO3H salt);GDC0941 dimethanesulfonate;GDC-0941;GDC0941;GDC 0941

     A pan inhibitor of class I PI3K isoforms GDC-0941 dimethanesulfonate Chemical Structure
  41. GC11177 GDC-0980 (RG7422)

    Apitolisib, RG7422

     GDC-0980 (RG7422) (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I PI3 kinase and mTOR kinase (TORC1/2) inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ, and with aKiof 17 nM for mTOR. GDC-0980 (RG7422) Chemical Structure
  42. GC10900 GDC-mTOR inhibitor GDC-mTOR inhibitor Chemical Structure
  43. GC64778 Gilmelisib Gilmelisib is an antineoplastic. Gilmelisib is a PI3K inhibitor (IC50 <1 nM for PI3K p110α) extracted from WO2017101847 A1, compound 1. Gilmelisib Chemical Structure
  44. GN10473 Ginkgolide C

    BN 52022, 1,7-dihydroxy Ginkgolide A

     Ginkgolide C Chemical Structure
  45. GN10584 Ginsenoside Rk1 Ginsenoside Rk1 Chemical Structure
  46. GC38606 Glaucocalyxin A Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect. Glaucocalyxin A Chemical Structure
  47. GC17338 GNE-317 potent, brain-penetrant PI3K inhibitor GNE-317 Chemical Structure
  48. GC10340 GNE-477 dual PI3K/mTOR inhibitor GNE-477 Chemical Structure
  49. GC68429 GNE-490 GNE-490 Chemical Structure
  50. GC15423 GNE-493

    Pan-PI3K/mTOR inhibitor

     GNE-493 Chemical Structure
  51. GC38787 GNF4877 GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6?nM and 16?nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66?μM for mouse β (R7T1) cells). GNF4877 Chemical Structure
  52. GC36178 Gomisin J A lignan with diverse biological activities Gomisin J Chemical Structure
  53. GC36186 GS-9901 GS-9901 is a highly selective and orally active PI3Kδ inhibitor, with an IC50 of 1 nM. GS-9901 Chemical Structure
  54. GC36190 GSK-3 inhibitor 1 GSK-3 inhibitor 1 is an inhibitor of GSK-3. GSK-3 inhibitor 1 Chemical Structure
  55. GC14987 GSK-3 Inhibitor IX (BIO)

    GSK-3 Inhibitor IX

     GSK-3 Inhibitor IX (BIO) (6-Bromoindirubin-3'-oxime; BIO) is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex with IC50s of 5 nM/320 nM/80 nM for (GSK-3α/β)/CDK1/CDK5, respectively. GSK-3 Inhibitor IX (BIO) Chemical Structure
  56. GC36193 GSK-3β inhibitor 1 GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM. GSK-3β inhibitor 1 Chemical Structure
  57. GC66032 GSK-3β inhibitor 11 GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research. GSK-3β inhibitor 11 Chemical Structure
  58. GC62338 GSK-3β inhibitor 3 GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia. GSK-3β inhibitor 3 Chemical Structure
  59. GC62423 GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1, an imidazole derivative, is an inhibitor of cdk5, cdk2, and GSK-3 extracted from patent WO2002010141A1, example 9a. GSK-3/CDK5/CDK2-IN-1 Chemical Structure
  60. GC16187 GSK-3β Inhibitor II

    Tip-oxadiazole

     GSK-3β inhibitor GSK-3β Inhibitor II Chemical Structure
  61. GC65309 GSK-F1 GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 Chemical Structure
  62. GC11018 GSK1059615 PI3K and mTOR inhibitor,potent and reversible GSK1059615 Chemical Structure
  63. GC33135 GSK2110183 GSK2110183 is the structural analogue of GSK2110183. GSK2110183 Chemical Structure
  64. GC33010 GSK2110183 hydrochloride GSK2110183 hydrochloride is the structural analogue of GSK2110183. GSK2110183 hydrochloride Chemical Structure
  65. GC15072 GSK2126458

    GSK212; GSK-2126458; GSK 2126458; GSK-212; GSK 212

     GSK2126458 (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2, respectively. GSK2126458 has anti-cancer activity. GSK2126458 Chemical Structure
  66. GC12305 GSK2141795

    GSK795, GSK2141795

     GSK2141795 (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. GSK2141795 Chemical Structure
  67. GC15595 GSK2269557 inhibitor of PI3Kδ GSK2269557 Chemical Structure
  68. GC15679 GSK2292767 PI3Kδ inhibitor,potent and selective GSK2292767 Chemical Structure
  69. GC12275 GSK2334470 PDK1 inhibitor,highly specific and potent GSK2334470 Chemical Structure
  70. GC64612 GSK251 GSK251 is a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode. GSK251 Chemical Structure
  71. GC17109 GSK2636771 GSK2636771 is a potent adenosine triphosphate competitive oral inhibitor of PI3Kβ, with an IC50 of 5.2 nmol/L against the catalytic subunit, p110β, whilst showing >900-fold selectivity over p110α and p110γ, and >10-fold selectivity over p110δ. GSK2636771 Chemical Structure
  72. GC43790 GSK3 Inhibitor XIII

    Glycogen Synthase Kinase 3 Inhibitor XIII

     GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 μM. GSK3 Inhibitor XIII Chemical Structure
  73. GC69196 GSK3 Substrate, α, β subunit

    GSK3 Substrate, α, β subunit is a peptide substrate of glycogen synthase kinase-3 (GSK-3) that can be used to measure GSK-3 activity.

     GSK3 Substrate, α, β subunit Chemical Structure
  74. GC66035 GSK3-IN-1 GSK3-IN-1 (compound 11) is a GSK-3 inhibitor with an IC50 value of 12 μM. GSK3-IN-1 can be used in the research of diabetes. GSK3-IN-1 Chemical Structure
  75. GC69195 GSK3-IN-3

    GSK3-IN-3 is a mitophagy inducer that can induce Parkin-dependent mitochondrial autophagy. It is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 has non-ATP and non-substrate competitive properties and has neuroprotective effects on 6-OHDA.

     GSK3-IN-3 Chemical Structure
  76. GC18810 GSK3β Inhibitor XI

    GSK3β inhibitor XI is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; Ki = 25 nM).

     GSK3β Inhibitor XI Chemical Structure
  77. GC11724 GSK621 AMPK agonist GSK621 Chemical Structure
  78. GC13696 GSK690693 GSK690693 is an ATP-competitive, low nanomolar inhibitor of Akt kinases with IC50 values of 2, 13, and 9 nM for Akt1, 2, and 3, respectively. GSK690693 Chemical Structure
  79. GC17658 Guggulsterone Broad spectrum steroid receptor ligand Guggulsterone Chemical Structure
  80. GA10282 H-Leu-OH

    Leu, NSC 46709, Pentanoic Acid

     H-Leu-OH Chemical Structure
  81. GC65460 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 Chemical Structure
  82. GC38088 Hederacolchiside A1 Hederacolchiside A1 Chemical Structure
  83. GC39266 Hematein Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells. Hematein Chemical Structure
  84. GC38168 Heterophyllin B Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. Heterophyllin B provides a novel strategy for the treatment of esophageal cancer. Heterophyllin B Chemical Structure
  85. GC64035 Hirsutenone Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone Chemical Structure
  86. GN10664 Honokiol

    NSC 293100

     Honokiol is a natural bisphenol chemical with multiple biological activities. It targets multiple signaling molecules and has effective antioxidant, anti-inflammatory, anti-angiogenic and anti-cancer activities. It also has broad-spectrum antibacterial and anti-human immunodeficiency virus (HIV) activities. Honokiol Chemical Structure
  87. GC16713 HS-173 novel PI3K inhibitor HS-173 Chemical Structure
  88. GC62572 hSMG-1 inhibitor 11e hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of 900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM). hSMG-1 inhibitor 11e Chemical Structure
  89. GC61925 hSMG-1 inhibitor 11j hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer. hSMG-1 inhibitor 11j Chemical Structure
  90. GC13185 HTH-01-015 NUAK1 inhibitor,highly specific and selective HTH-01-015 Chemical Structure
  91. GC69242 HTH-01-091

    HTH-01-091 is a potent and selective inhibitor of maternal embryonic leucine zipper kinase (MELK), with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be used for breast cancer research.

     HTH-01-091 Chemical Structure
  92. GC72931 HTH-01-091 TFA HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 TFA Chemical Structure
  93. GC73637 HTH-02-006 HTH-02-006 is a NUAK2 inhibitor (IC50 = 126 nM). HTH-02-006 Chemical Structure
  94. GC73729 IBL-302

    AMU302

     IBL-302 (AMU302) is an orally available dual-signaling inhibitor of PIM and PI3K/AKT/mTOR with activity against breast cancer and neuroblastoma. IBL-302 Chemical Structure
  95. GC15540 IC-87114 PI3Kδ inhibitor IC-87114 Chemical Structure
  96. GC62465 Idelalisib D5

    CAL-101 D5; GS-1101 D5

     Idelalisib D5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor. Idelalisib D5 Chemical Structure
  97. GC63017 IHMT-PI3Kδ-372 IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 Chemical Structure
  98. GC19411 IITZ-01 IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. IITZ-01 Chemical Structure
  99. GC16617 IM-12

    GSK3β Inhibitor XIX

     GSK-3β inhibitor, potent IM-12 Chemical Structure
  100. GC13503 iMDK PI3K and endogenous midkine (MDK) expression inhibitor iMDK Chemical Structure
  101. GC62376 iMDK quarterhydrate iMDK quarterhydrate is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice. iMDK quarterhydrate Chemical Structure

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