MAPK Signaling

FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.

Fucoxanthin (all-trans-Fucoxanthin) is a naturally occurring carotenoid widely distributed in edible brown seaweed and diatoms.

p-Methylphenyl potassium sulfate is a prototype protein-binding uremic toxin associated with the progression of chronic kidney disease, cardiovascular risk and mortality, derived from tyrosine and phenylalanine metabolites in the liver.

A PKA substrate

Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.

AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM.

PF-06260933 is an orally active and highly selective inhibitor of MAP4K4 with IC50s of 3.7 and 160 nM for kinase and cell, respectively.

Dilmapimod (SB-681323) (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

A lignan with anti-inflammatory and anticancer activities

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

p38α inhibitor 1 is a p38α inhibitor extracted from patent WO 2008076265 A1.

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis Wright, with antitumor activity; Deltonin inhibits ERK1/2 and AKT activation.

FR 167653 (FR 167653 sulfate) (FR 167653 (FR 167653 sulfate) sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.

A TAK1 inhibitor

APTO-253 (LOR-253) is a small-molecule inducer of Krüppel-like factor 4 (KLF4) with antiproliferative activity against acute myeloid leukemia and lymphoma cell lines, with IC₅₀ values of 57nM-1.75μM.

Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.

An ERK5 inhibitor

AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity.

CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.

SLV-2436 (SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50s of 10.8 nM and 5.4 nM, respectively.

An inhibitor of B-RAF and C-RAF

Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activities.