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Home >> Signaling Pathways >> MAPK Signaling >> MAP3K

MAP3K

MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, modulate many biological processes, such as growth, development and various environmental stresses. Based on the sequence of their kinase catalytic domain, MAP3Ks are classified into three groups: the MEKK-like, ZIK-like and Raf-like families. Raf-like MAP3Ks constitute largest MAP3K subfamily. Raf-like MAP3Ks play roles in response to biotic and abiotic stresses.

MAP3Ks often bind to both MAP4Ks and MAP2Ks in the same pathway. For example, MEKK1 (MAP3K1) binds to both the MAP4K NIK and the MAP2K MKK4, while NSY-1 (MAP3K) binds to the MAP2K SEK-1. MAP3Ks activates MAP2Ks by phosphorylation of a serine and/or threonine, and MAP2Ks activate MAPKs by dual phosphorylation of a Thr-X-Tyr motif.

Targets for  MAP3K

Products for  MAP3K

  1. Cat.No. Product Name Information
  2. GC13944 (5Z)-7-Oxozeaenol

    FR148083,L-783,279,LL-Z 1640-2

    TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

     (5Z)-7-Oxozeaenol Chemical Structure
  3. GC79474 (E/Z)-ASK1-IN-4 (E/Z)-ASK1-IN-4 is an isomer of ASK1-IN-4. (E/Z)-ASK1-IN-4 Chemical Structure
  4. GC19041 ASK1-IN-1 ASK1-IN-1 is a potent, orally available and selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 of 2.87 nM. ASK1-IN-1 Chemical Structure
  5. GC62426 ASK1-IN-2 ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 Chemical Structure
  6. GC12151 B-Raf inhibitor B-Raf inhibitor Chemical Structure
  7. GC43304 Compound 43 TAO Kinase Inhibitor Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively). Compound 43 TAO Kinase Inhibitor Chemical Structure
  8. GC35734 Cot inhibitor-1 Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC50 of 28 nM. Cot inhibitor-1 Chemical Structure
  9. GC35735 Cot inhibitor-2 Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM. Cot inhibitor-2 Chemical Structure
  10. GC30913 DLK-IN-1 DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 Chemical Structure
  11. GC19173 GNE-3511 GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM. GNE-3511 Chemical Structure
  12. GC70391 GNE-8505 GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). GNE-8505 Chemical Structure
  13. GC13514 NG25 NG25 is a potent and cell-permeable inhibitor of transforming growth factor-β-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2), with IC50 values of 149nM and 21.7nM, respectively. NG25 Chemical Structure
  14. GC17577 NQDI 1 A selective inhibitor of ASK1 NQDI 1 Chemical Structure
  15. GC63144 PF-05381941 PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively. PF-05381941 Chemical Structure
  16. GC36898 Phosphocreatine Phosphocreatine is a high-energy phosphate compound that is abundant in muscle and brain. Phosphocreatine Chemical Structure
  17. GC12124 Selonsertib (GS-4997)

    GS-4977, GS-4997

     Selonsertib (GS-4997) (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Selonsertib (GS-4997) Chemical Structure
  18. GC62675 SM1-71 SM1-71 (compound 5) is a potent TAK1 inhibitor, with a Ki of 160 nM, it also can covalently inhibit MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2. SM1-71 can inhibit proliferation of multiple cancer cell lines. SM1-71 Chemical Structure
  19. GC62497 TAK1-IN-2 TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM. TAK1-IN-2 Chemical Structure
  20. GC69984 TAK1-IN-4

    TAK1-IN-4 (Compound 14) is a TAK1 inhibitor.

     TAK1-IN-4 Chemical Structure
  21. GC32687 Takinib

    EDHS-206

     A TAK1 inhibitor Takinib Chemical Structure
  22. GC79478 TAO Kinase-IN-3 TAO Kinase-IN-3 is a potent pan- TAOK ( Thousand-And-One Kinase ) inhibitor that specifically binds to and inhibits the kinase activities of TAOK1, TAOK2 and TAOK3 with K d values of <0.17 nM, 0.34 nM, and 0.17 nM, respectively. TAO Kinase-IN-3 Chemical Structure
  23. GC14853 TC ASK 10 ASK1 inhibitor TC ASK 10 Chemical Structure
  24. GC45067 Tpl2 Kinase Inhibitor

    c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor

     Tpl2 Kinase Inhibitor (TKI) is a cell-permeable naphthyridine compound that acts as a potent reversible and ATP-competitive inhibitor of Tpl2 kinase. Tpl2 Kinase Inhibitor Chemical Structure
  25. GC49150 Tpl2 Kinase Inhibitor (hydrochloride)

    c-Cot Kinase Inhibitor, MAP3K8 Kinase Inhibitor, Tumor Progression Locus 2 Kinase Inhibitor

     A Tpl2 inhibitor Tpl2 Kinase Inhibitor (hydrochloride) Chemical Structure

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