MAPK Signaling

ERK1/2 inhibitor 9 (Probe 1) is a covalent ERK1/2 inhibitor.

MS934 is a novel improved VHL-recruiting MEK 1/2 degrader.

BLU0588 is an orally active, potent and selective PRKACA (protein kinase cAMP-activated catalytic subunit alpha) kinase inhibitor, with an IC50 of 1 nM and dissociation constant (Kd) of 4 nM.

MAPK-IN-2 (compound 3h) is a potent MAPK inhibitor with antineoplastic activity.

LUNA18 is an orally-available cyclic peptide KRAS and ERK inhibitor.

ERK5-IN-5 (compound 4a) is an ERK5 kinase inhibitor with anticancer activity.

RMC-4998 is an orally active inhibitor targeting the active or GTP-bound state of the KRASG12C mutant.

TAS0612 is an orally novel inhibitor of RSK、AKT and S6K.

NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation.

INS018 055 (compound 112) is a TNIK and MAP4K4 inhibitor with IC50 values of 12-120, 12-120 nM, respectively.

VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2.

JNK-IN-13 (compound 1) is a potent and selective JNK inhibitor with IC50s of 290 nM and 500 nM for JNK3 and JNK2, respectively.

CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin.

Serum tmic factor acetate (Tmulin acetate) is the acetate salt form of Serum tmic factor.

NN3201 is a c-Kit -targeting antibody-drug conjugate ( ADC ) with high affinity ( K D = 0.19 pM).

WJH-C19 is an orally active RIPK1 inhibitor with an IC 50 of 5.7 nM.

DDO-6600 is a covalent Hsp90 inhibitor.

WX2-43 is a PRMT5-KLF4 inhibitor ( K d of 11.0 nM).

YZ-836P is a Protein arginine methyltransferase 5 ( PRMT5 ) targeting agent.

Semaglutide -FITC (Semaglutide-Lys(FITC)) is a fluorescent tracer probe (Ex/Em = 495/520 nm) obtained by covalently coupling the green fluorescent dye fluorescein isothiocyanate (FITC) to the long-acting analogue of GLP-1, Semaglutide.

Semaglutide, Cy5-labeled (Semaglutide-Cys(Cy5)) is a CY5 -labeled version of Semaglutide (Ex/Em = 633/670 nm).

Peptide R54 acetate (Pep R54 acetate) is a CXCR4 antagonist.

BBO-11818 is an orally active, highly selective (relative to NRAS and HRAS ), non-covalent pan- KRAS inhibitor ( IC 50 =28-120 nM).

RMC-4998 TFA is an orally active inhibitor targeting the active or GTP-bound state of the KRAS G12C mutant.