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DDO-6600

Catalog No.GC79077 Copy One-Click Copy Product Info

DDO-6600 is a covalent Hsp90 inhibitor.

Products are for research use only. Not for human use. We do not sell to patients.

DDO-6600 Chemical Structure

Cas No.: 2640292-37-9

Size Price Stock Qty
1mg
$153.00
In stock
5mg
$383.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of DDO-6600

DDO-6600 is a covalent Hsp90 inhibitor. DDO-6600 disrupts the interaction between Hsp90 and its co-chaperone protein Cdc37, thereby inducing the degradation of kinase client proteins (such as AKT, CDK4, c-Raf ). DDO-6600 has inhibitory activity against various cancer cells. DDO-6600 inhibits the migration and invasion of HCT-116 cells, and induces cell cycle arrest and apoptosis. DDO-6600 significantly inhibits tumor growth in the HCT-116 xenograft tumor model. DDO-6600 can be used for research on colorectal cancer [1].

References:
[1]. Li L, et al. Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification. Cell Chem Biol. 2021 Oct 21;28(10):1446-1459.e6.

Chemical Properties of DDO-6600

Cas No. 2640292-37-9 SDF
Formula C26H28N4O2 M.Wt 428.53
Solubility Storage Store at -20°C
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of DDO-6600

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1 mg 5 mg 10 mg
1 mM 2.3336 mL 11.6678 mL 23.3356 mL
5 mM 466.7 μL 2.3336 mL 4.6671 mL
10 mM 233.4 μL 1.1668 mL 2.3336 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for DDO-6600

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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