GLPBio

MAPK Signaling

Research Areas

Products Related to MAPK Signaling(660)

  • GC12297 structure
    GC12297AT7867
    CAS: 857531-00-1
    Purity: >98.00%

    Akt1/2/3 and p70S6K/PKA inhibitor

  • GC12304 structure
    GC12304OTS514
    CAS: 1338540-63-8
    Purity: >98.00%

    TOPK inhibitor,highly potent

  • GC12406 structure
    GC12406RO5126766(CH5126766)
    CAS: 946128-88-7
    Purity: >98.00%

    RO5126766(CH5126766) (CH5126766) is a first-in-class dual MEK/RAF inhibitor that allosterically inhibits BRAFV600E, CRAF, MEK, and BRAF (IC50: 8.2, 56, 160 nM, and 190 nM, respectively).

  • GC12482 structure
    GC12482BRAF inhibitor
    CAS: 918505-61-0
    Purity: >98.50%
  • GC12486 structure
    GC12486Dabrafenib Mesylate (GSK-2118436)
    CAS: 1195768-06-9
    Purity: >99.50%

    A Raf kinase inhibitor

  • GC12532 structure
    GC12532CHPG
    CAS: 170846-74-9
    Purity: >98.00%

    CHPG is a selective metabotropic glutamate receptor 5 (mGlu5) agonist.

  • GC12646 structure
    GC12646AL 8697
    CAS: 1057394-06-5
    Purity: >99.00%

    p38α inhibitor,potent and selective

  • GC12691 structure
    GC12691XMD17-109
    CAS: 1435488-37-1
    Purity: >98.00%

    A selective ERK5 inhibitor

  • GC12799 structure
    GC12799H-8 (hydrochloride)
    CAS: 113276-94-1
    Purity: >98%

    H-8 (dihydrochloride) is a cell-permeable, reversible and ATP-competitive PKA inhibitor.

  • GC12807 structure
    GC12807U0126-EtOH
    CAS: 1173097-76-1
    Purity: >98.00%

    U0126-EtOH is a non-ATP competitive and selective inhibitor of MEK1 and MEK2 with IC 50 values of 72nM and 58nM, respectively.

  • GC12834 structure
    GC128346-Bnz-cAMP sodium salt
    CAS: 1135306-29-4
    Purity: >98%

    cAMP analog,PKA activator

  • GC12841 structure
    GC12841CEP 1347
    CAS: 156177-65-0
    Purity: >98%

    JNK inhibitor

  • GC12851 structure
    GC1285110Z-Hymenialdisine
    CAS: 82005-12-7
    Purity: >98%

    Pan kinase inhibitor

  • GC12882 structure
    GC12882AS 602801
    CAS: 848344-36-5
    Purity: >99.50%

    A selective, orally bioavailable JNK inhibitor

  • GC12982 structure
    GC12982BIX 02565
    CAS: 1311367-27-7
    Purity: >99.00%

    RSK2 inhibitor

  • GC12989 structure
    GC12989PD184352 (CI-1040)
    CAS: 212631-79-3
    Purity: >99.50%

    PD184352 (CI-1040) (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1.

  • GC13115 structure
    GC13115VX-11e
    CAS: 896720-20-0
    Purity: >99.00%

    A selective ERK inhibitor

  • GC13116 structure
    GC13116JX 401
    CAS: 349087-34-9
    Purity: >98%

    p38α inhibitor

  • GC13142 structure
    GC13142RWJ 67657
    CAS: 215303-72-3
    Purity: >99.00%

    orally active inhibitor of the MAP kinases p38α and p38β

  • GC13244 structure
    GC13244DTP3
    CAS: 1809784-29-9
    Purity: >99.00%

    inhibitor of GADD45β/MKK7 complex

  • GC13412 structure
    GC13412Vemurafenib (PLX4032, RG7204)
    CAS: 918504-65-1
    Purity: >99.00%

    Vemurafenib (PLX4032, RG7204) is a selective and potent inhibitor of B-RAF with IC 50 values of 31 and 48nM for BRAF V600E and c-RAF-1, respectively.

  • GC13508 structure
    GC13508Trametinib (GSK1120212)
    CAS: 871700-17-3
    Purity: >98.00%

    Trametinib (GSK1120212) is a highly selective MEK1/2 allosteric inhibitor. Trametinib inhibits MEK1/2 (IC 50 =2nM) phosphorylation of ERK to block the RAS-RAF-MEK-ERK/MAPK pathway.

  • GC13514 structure
    GC13514NG25
    CAS: 1315355-93-1
    Purity: >98.00%

    NG25 is a potent and cell-permeable inhibitor of transforming growth factor-β-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2), with IC 50 values of 149nM and 21.7nM, respectively.

  • GC13578 structure
    GC13578Skepinone-L
    CAS: 1221485-83-1
    Purity: >99.50%

    An inhibitor of p38 MAPK