MAPK Signaling

ribosomal S6 kinase inhibitor

TAK-715 is a potent, selective, and orally active p38 mitogen-activated protein kinase (p38 MAPK) inhibitor, with IC 50 values of 7.1nM and 200nM for p38α and p38β, respectively.

LGX818 (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM).

P90 RSK inhibitor

LY2228820 (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC50s of 5.3 and 3.2 nM, respectively.

8-Bromo-cAMP (8-Bromo-cAMP, sodium salt) is a cell-permeable cAMP analogue that acts as a CAMP-dependent protein kinase activator (PKA activator).

P38α MAPK inhibitor,highly selective and ATP-competitive

P38 MAPK inhibitor

Pimasertib (AS-703026) (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor.

Selective and orally available ERK1/2 inhibitor

Ac-muramyl-Ala-D-Glu-NH₂ (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln.

A PDE10A inhibitor

AS601245 is a potent ATP-competitive JNK inhibitor with IC 50 values of 0.15µM, 0.22, and 0.07µM for JNK1, JNK2, and JNK3, respectively.

Cobimetinib is a potent and selective inhibitor of MEK1 with an IC 50 value of 0.9nM.

A selective p38 MAPK inhibitor

P38 MAP kinase inhibitor, potent and selective

Piperlongumine is a natural alkaloid compound extracted from Piper longum L. , which has multiple pharmacological activities, including anti-tumor, lipid metabolism regulation, anti-platelet aggregation and analgesic activities.

paradox-breaker RAF inhibitor, potent and selective

PD0325901 is an orally active, selective and non-ATP-competitive mitogen-activated protein kinase kinase (MEK) inhibitor with an IC 50 value of 0.33nM.

p38α and p38β2 inhibitor

PKA activator

A potent JNK inhibitor

B-Raf inhibitor,potent and selective

p38 MAPK inhibitor