GLPBio

MAPK Signaling

Research Areas

Products Related to MAPK Signaling(660)

  • GC13640 structure
    GC13640Kemptide
    CAS: 65189-71-1
    Purity: >96.50%

    substrate for cAMP-dependent protein kinase (PKA)

  • GC13724 structure
    GC13724JIP-1 (153-163)
    CAS: 438567-88-5
    Purity: >98%

    Peptide inhibitor of c-Jun N-terminal kinase (JNK)

  • GC13825 structure
    GC13825TA 01
    CAS: 1784751-18-3
    Purity: >99.50%

    CK1ε, CK1δ,and p38α inhibitor

  • GC13841 structure
    GC13841JNK-IN-8
    CAS: 1410880-22-6
    Purity: >99.50%

    JNK-IN-8 is the first irreversible JNK inhibitor that acts on JNK1, JNK2, and JNK3 with high specificity, with IC 50 values of 4.7 nM, 18.7 nM, and 1 nM in the A375 cell line, respectively.

  • GC13869 structure
    GC13869Fasudil
    CAS: 103745-39-7
    Purity: >98.00%

    Fasudil (HA-1077; AT877) is a non-specific RhoA/ROCK inhibitor with a K i of 0.33μM and an IC 50 of 0.158μM for ROCK1, and IC 50 of 4.58μM, 12.30μM, and 1.650μM for ROCK2, PKA, PKC, and PKG, respectively.

  • GC13944 structure
    GC13944(5Z)-7-Oxozeaenol
    CAS: 66018-38-0,253863-19-3
    Purity: >99.00%

    TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

  • GC13980 structure
    GC13980LY3009120
    CAS: 1454682-72-4
    Purity: >99.00%

    LY3009120 is a pan-RAF inhibitor with IC 50 values of 5.8, 9.1, and 15nM for RAF V600E , BRAF WT , and CRAF WT , respectively.

  • GC14114 structure
    GC14114DB07268
    CAS: 929007-72-7
    Purity: >98.50%

    A potent inhibitor of JNK1

  • GC14125 structure
    GC14125FMK
    CAS: 821794-92-7
    Purity: >98.00%

    An inhibitor of RSK2

  • GC14197 structure
    GC14197CC-401 hydrochloride
    CAS: 1438391-30-0
    Purity: >99.50%

    A potent, specific pan-JNK inhibitor

  • GC14289 structure
    GC14289Fasudil (HA-1077) HCl
    CAS: 105628-07-7
    Purity: >98.00%

    Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil (HA-1077) HCl is also a potent Ca2+ channel antagonist and vasodilator.

  • GC14337 structure
    GC14337Cobimetinib (R-enantiomer)
    CAS: 934660-94-3
    Purity: >98%
  • GC14459 structure
    GC14459SB 747651A dihydrochloride
    CAS: 1781882-72-1
    Purity: >98.00%

    SB 747651A dihydrochloride is a novel, orally active ATP-competitive inhibitor of mitogen- and stress-activated protein kinase 1 (MSK1; IC₅₀=11nM).

  • GC14534 structure
    GC14534Regorafenib monohydrate
    CAS: 1019206-88-2
    Purity: >99.50%

    A multi-kinase inhibitor

  • GC14606 structure
    GC14606Regorafenib hydrochloride
    CAS: 835621-07-3
    Purity: >99.50%

    A multi-kinase inhibitor

  • GC14645 structure
    GC14645PF-3644022
    CAS: 1276121-88-0
    Purity: >98.00%

    Potent and Selective MK2 inhibitor

  • GC14647 structure
    GC14647SCH772984 HCl
    Purity: >98%

    ERK1/2 inhibitor

  • GC14693 structure
    GC14693CMK
    CAS: 821794-90-5
    Purity: >99.50%
  • GC14732 structure
    GC14732PLX-4720
    CAS: 918505-84-7
    Purity: >99.50%

    An orally-available inhibitor of the B-raf mutant B-Raf V600E

  • GC14853 structure
    GC14853TC ASK 10
    CAS: 1005775-56-3
    Purity: >99.00%

    ASK1 inhibitor

  • GC14899 structure
    GC14899AMG 548
    CAS: 864249-60-5
    Purity: >98%

    P38α inhibitor,potent and selective

  • GC14938 structure
    GC14938PF-03394197(Oclacitinib)
    CAS: 1208319-26-9
    Purity: >98%

    Novel Janus kinase inhibitor

  • GC14982 structure
    GC14982SD 169
    CAS: 1670-87-7
    Purity: >99.00%

    selective ATP competitive inhibitor of the MAP kinases p38α and p38β

  • GC15004 structure
    GC15004URMC-099
    CAS: 1229582-33-5
    Purity: >99.50%

    URMC-099, as a 7‐azaindole‐based MLK3 inhibitor with IC 50 of 14 nM, could specifically affect specific Aβ species engaged in disease pathobiology.