MAPK Signaling
Research Areas
Products Related to MAPK Signaling(660)
- GC15299Staurosporine(CGP 41251)CAS: 62996-74-1Purity: >99.50%
Staurosporine, a small kinase inhibitor, is an alkaloid derived from the bacterium Streptomyces staurosporeus .
- GC153528-CPT-Cyclic AMP (sodium salt)CAS: 93882-12-3Purity: >98.00%
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA).
- GC15611Rp-8-Br-PET-cGMPSCAS: 185246-32-6Purity: >98.00%
cGMP-dependent protein kinase (PKG) inhibitor
- GC15814Pamapimod (R-1503, Ro4402257)CAS: 449811-01-2Purity: >99.50%
Pamapimod (R-1503, Ro4402257) (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively.
- GC16511OTS964CAS: 1338545-07-5Purity: >99.00%
OTS964 is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC15028 | JNK-IN-7 | 1408064-71-0 | >98.00% | |
A non-selective JNK inhibitor | ||||
| GC15044 | SCH772984 TFA | - | >98% | |
ERK1/2 inhibitor | ||||
| GC15061 | U0124 | 108923-79-1 | >98% | |
Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative control | ||||
| GC15240 | APS-2-79 | 2002381-31-7 | >99.00% | |
APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling. | ||||
| GC15260 | Trametinib DMSO solvate | 1187431-43-1 | >99.50% | |
| GC15296 | ML 786 dihydrochloride | 1237536-18-3 | - | |
Raf kinase inhibitor | ||||
| GC15299 | Staurosporine(CGP 41251) | 62996-74-1 | >99.50% | |
Staurosporine, a small kinase inhibitor, is an alkaloid derived from the bacterium Streptomyces staurosporeus . | ||||
| GC15352 | 8-CPT-Cyclic AMP (sodium salt) | 93882-12-3 | >98.00% | |
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). | ||||
| GC15477 | DBM 1285 dihydrochloride | - | >98% | |
p38 MAPK inhibitor | ||||
| GC15611 | Rp-8-Br-PET-cGMPS | 185246-32-6 | >98.00% | |
cGMP-dependent protein kinase (PKG) inhibitor | ||||
| GC15646 | PD 184161 | 212631-67-9 | >98% | |
MEK1/2 inhibitor | ||||
| GC15693 | BIX 02188 | 334949-59-6 | >99.50% | |
MEK5 inhibitor,potent and selective | ||||
| GC15814 | Pamapimod (R-1503, Ro4402257) | 449811-01-2 | >99.50% | |
Pamapimod (R-1503, Ro4402257) (Ro4402257) is a potent, selective and orally active p38 MAPK inhibitor with IC50s of 14 nM and 480 nM and Kis of 1.3 nM and 120 nM for p38α and p38β, respectively. | ||||
| GC15818 | RAF265 | 927880-90-8 | >99.50% | |
Multiple intracellular kinases inhibitor | ||||
| GC15924 | L-779,450 | 303727-31-3 | >98.50% | |
Raf kinase inhibitor | ||||
| GC16001 | SCH772984 | 942183-80-4 | >98.50% | |
SCH772984 is a novel, potent, ATP-competitive inhibitor of ERK1 and ERK2 with IC 50 values of 4nM and 1nM, respectively. | ||||
| GC16007 | Methylthiouracil | 56-04-2 | >98.00% | |
antithyroid preparation | ||||
| GC16019 | SB 202474 | 172747-50-1 | >98% | |
a negative control in studies of p38 inhibition | ||||
| GC16039 | LJH685 | 1627710-50-2 | >98.00% | |
RSK (p90 ribosomal S6 kinase) inhibitor | ||||
| GC16169 | XRP44X | 729605-21-4 | >98% | |
Ras-Net (Elk-3) pathway inhibitor | ||||
| GC16214 | DEL-22379 | 181223-80-3 | >98.00% | |
inhibitor of the dimerization of ERK | ||||
| GC16511 | OTS964 | 1338545-07-5 | >99.00% | |
OTS964 is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM. | ||||
| GC16601 | LJI308 | 1627709-94-7 | >99.00% | |
pan-RSK inhibitor | ||||
| GC16652 | SR 3576 | 1164153-22-3 | >98% | |
JNK3 inhibitor, potent and selective | ||||