PI3K/Akt/mTOR Signaling

A66 is a highly specific and selective p110α inhibitor with an IC 50 value of 32nM.

Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent.

Guggulsterone is a plant sterol extracted from the resin of the plant Commiphora wightii. Guggulsterone can inhibit the growth of a wide variety of tumor cells and induce apoptosis through downregulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP, and survivin), modulation of cell cycle proteins (such as Cyclin D1 and c-Myc), activation of caspases, inhibition of Akt, and activation of JNK.

Mast cell membrane stabilizer

A selective PI3K/mTOR kinase inhibitor

A cell-permeable inhibitor of CK2

CHPG Sodium salt is a selective metabotropic glutamate receptor 5 (mGlu5) agonist.

Akt/PKB inhibitor

Nordihydroguaiaretic acid is a potent 5-lipoxygenase (5-LOX) inhibitor with an IC 50 value of 8μM.

YLF-466D is an orally bioavailable activator of AMP-activated protein kinase (AMPK), an enzyme involved in regulation of cellular energy homeostasis.

Yoda1 is an effective selective agonist of Piezo1 with an EC 50 value of 17.1μM in mice.

Akt1, 2, and 3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.

API-1 is an inhibitor of Akt that reduces the level of phosphorylated Akt (IC50 = ~0.8 uM in OVCAR3 cells) by binding to Akt and blocking its translocation to the cell membrane.

SAR260301 is an inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform β (IC50 = 52 nM).

D-α-Hydroxyglutaric Acid is a weak competitive antagonist of α‑ketoglutarate (α‑KG) (K i = 10.87mM).

GSK3β inhibitor XI is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; Ki = 25 nM).

D-Cyclins regulate the cell cycle by acting in a complex with cyclin dependent kinases (CDKs) to promote phosphorylation of the retinoblastoma protein and initiate cellular progression from the G1 to the S phase.

CAY10626 is a PI3Kα/mTOR dual kinase inhibitor. CAY10626 has IC50s of 0.9, 0.6 nM for PI3Kα and mTOR, respectively. CAY10626 can be used for the research of cancer.

ARQ-092 (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.

CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor with IC50 of 6.8 nM.

CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07.

ETP-46321 is a potent and orally bioavailable PI3Kα and PI3Kδ inhibitor with Kiapps of 2.3 and 14.2 nM, respectively.

GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM.