PI3K/Akt/mTOR Signaling

Isopsoralidin is a phosphatidylinositol 3-kinase ( PI3K ) inhibitor with potential hepatotoxicity and CYP2D6 inhibitory activity [1] .

PDKtide TFA, a biological active peptide, is a substrate for phosphatidylinositide-dependent kinase 1 ( PDK1 ) [1] .

Tovophyllin A is an orally active xanthonoid compound.

ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability.

PROTAC HIF-1α degrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. PROTAC HIF-1α degrader-2 promotes HIF-1α degradation via the ubiquitin-proteasome pathway by facilitating the formation of a HIF-1α/VHL ternary complex.

GP262 is a PI3K/mTOR PROTAC degrader targeting PI3Kγ, PI3Kα and mTOR with DC 50 values of 42.23 nM, 227.4 nM and 45.4 nM, respectively in MDA-MB-231 cells.

PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC ( PI3K / mTOR ).

PDGFRA/CAIX/XII-IN-1 is an inhibitor of PDGFRA, CA IX and CA XII, with an IC 50 of 20 nM against PDGFRA, a K i of 93.3 nM against CA IX, and a K i of 80.0 nM against CA XII.

FGF7p is a small molecule peptide and a potential bladder protector.

VEGFR2-IN-84 is an orally active, multi-targeted tyrosine kinase inhibitor based on a naphthalene ring scaffold.

E8431 is a DCSTAMP antagonist with an IC 50 value of 775.8 nM for osteoclastogenesis.

FOXM1-IN-3 is a potent FOXM1 inhibitor.

FZ1 peptide is a cyclic heptapeptide and also an integrin αvβ3 agonist.

DX-8951 Hydroxy-acid sodium is a prodrug of phosphoramide.

YHV98-4 is a selective, blood-brain barrier-permeable Hv1 inhibitor with an IC 50 of 0.7 μM.

Sialorphin TFA is a neutral endopeptidase ( NEP ) and aminopeptidase N ( APN ) inhibitor that responds to androgen signals.

CK37 is a competitive choline kinase-α inhibitor.

Nivitol (UP302) is a natural phenolic compound discovered from Dianella ensifolia and also acts as a Tyrosinase inhibitor.

YJ1206 TFA is an orally active selective CDK12 / CDK13 PROTAC degrader.

Ciprofloxacin hydrochloride (Bay-09867 hydrochloride) is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent.

Vevorisertib tetrahydrochloride (ARQ 751 tetrahydrochloride) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation.

An internal standard for the quantification of 5-bromopentanoic acid

An Akt activation inhibitor and active metabolite of triciribine

An allosteric PI3Kα activator