PI3K/Akt/mTOR Signaling

Akt-I-1 is an inhibitor of Akt1 (IC50 = 4.6 µM).

SB-02024 is an inhibitor of vacuolar protein sorting 34 (VPS34; IC50 = 5 nM).

Lipoteichoic acid is a teichoic acid predominantly located in the cell walls of Gram-positive bacteria, widely involved in stimulating immune responses and cellular signaling pathways.

Hecubine is a natural aspidosperma-type alkaloid found in E. officinalis , with anti-neuroinflammation properties.

Isorhamnetin is a flavonoid compound extracted from the traditional Chinese medicine Hippophae rhamnoides L., possessing various biological activities including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects.

6-gingerol is an active compound isolated from Ginger with anticancer, anti-inflammation, and anti-oxidation activities.

Salidroside is a tyrosol glycoside primarily found in the roots of Rhodiola species, exhibiting a wide range of biological and pharmacological properties, including anti-cancer, antioxidant, anti-aging, anti-diabetic, anti-hypertensive, anti-inflammatory, and immunomodulatory effects.

Quercetin is an important dietary flavonoid, present in vegetables, fruits, seeds, nuts, tea and red wine.

Dihydromyricetin is a natural flavanonol isolated from A. grossedentata and H. dulcis that has antioxidant, antiproliferative, anti-apoptotic, and anti-alcohol intoxication properties.

Scutellarin is a flavonoid with multiple biological activities.

Artemisinine is a sesquiterpene lactone antimalarial drug extracted from the plant Artemisia annua .

Honokiol is a natural bisphenol chemical with multiple biological activities. It targets multiple signaling molecules and has effective antioxidant, anti-inflammatory, anti-angiogenic and anti-cancer activities. It also has broad-spectrum antibacterial and anti-human immunodeficiency virus (HIV) activities.

Oridonin is an inhibitor of protein kinase B (AKT; PKB), with IC 50 values of 8.4 and 8.9μM for AKT1 and AKT2 respectively.

Measures the activity of kinases that phosphorylate ribosomal protein S6.

TWS119 is a highly potent and selective inhibitor of glycogen synthase kinase-3β (GSK-3) with K D value of 126nM and IC 50 value of 30nM.