GLPBio

TGF-β / Smad Signaling

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Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Research Areas

Products Related to TGF-β / Smad Signaling(398)

  • GN10463 structure
    GN10463Chelerythrine
    CAS: 34316-15-9
    Purity: >98.00%
  • GN10534 structure
    GN10534Asiaticoside
    CAS: 16830-15-2
    Purity: >98.00%

    Asiaticoside is a pentacyclic triterpenoid glycoside extracted from Centella asiatica .

  • GC11499 structure
    GC11499Enzastaurin (LY317615)
    CAS: 170364-57-5
    Purity: >99.50%

    Enzastaurin (LY317615) is an ATP-competitive and selective inhibitor of PKCβ with an IC 50 value of 6nM.

  • GC15281 structure
    GC15281K-252c
    CAS: 85753-43-1
    Purity: >99.00%

    Protein kinase inhibitor

  • GC15420 structure
    GC15420ICP 103
    Purity: >98.00%

    Protein kinase inhibitor

  • GC15431 structure
    GC15431GF 109203X (Bisindolylmaleimide I)
    CAS: 133052-90-1
    Purity: >99.00%

    GF 109203X is a selective inhibitor of protein kinase C, selective for the α and β1 isoforms with IC 50 values of 0.0084, 0.0180, 0.210, 0.132, and 5.8μM for α, β1, δ, ε and ζ isoforms of protein kinase C respectively.

  • GC15520 structure
    GC15520Sotrastaurin (AEB071)
    CAS: 425637-18-9
    Purity: >99.50%

    Sotrastaurin (AEB071) is a potent and orally-active pan-protein kinase C (PKC) inhibitor, with Ki values of 0.22nM, 0.64nM, 0.95nM, 1.8nM, 2.1nM and 3.2nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively.

  • GC16907 structure
    GC16907Go 6983
    CAS: 133053-19-7
    Purity: >99.00%

    Go 6983 is a pan-PKC inhibitor that acts on PKCα, PKCβ, PKCγ, PKCδ, andPKCμ with IC 50 values of 7nM, 7nM, 6nM, 10nM, and 20μM, respectively.

  • GC14701 structure
    GC14701Zoledronic Acid
    CAS: 118072-93-8
    Purity: >99.00%

    Zoledronic Acid is a third-generation nitrogen-containing bisphosphonate bone resorption inhibitor.

  • GC17936 structure
    GC17936GSK269962A
    CAS: 850664-21-0
    Purity: >99.50%

    ROCK inhibitor

  • GC12790 structure
    GC12790Pirfenidone
    CAS: 53179-13-8
    Purity: >98.00%

    Pirfenidone (AMR69) is an orally active antifibrotic drug that attenuates the production of chemokines CCL2 and CCL12 in fibrocytes .

  • GC16354 structure
    GC16354Dequalinium Chloride
    CAS: 522-51-0
    Purity: >98.00%

    anti-tumor agent and PKC inhibitor

  • GC17322 structure
    GC17322Ro 31-8220
    CAS: 125314-64-9
    Purity: >98.00%

    pan-PKC inhibitor

  • GC10496 structure
    GC10496Midostaurin (PKC412)
    CAS: 120685-11-2
    Purity: >98.00%

    Midostaurin (PKC412) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits multiple kinases, including FLT3, KIT, PDGFR, and VEGFR (IC 50 = 22-500nM).