TGF-β / Smad Signaling
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Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
Research Areas
Products Related to TGF-β / Smad Signaling(358)
- GC15471PKC β pseudosubstrateCAS: 172308-76-8Purity: >98%
Selective cell-permeable peptide inhibitor of protein kinase C
- GC15884Dasatinib MonohydrateCAS: 863127-77-9Purity: >98%
Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases.
- GC15892Cetrimonium Bromide (CTAB)CAS: 57-09-0Purity: >98.00%
Cetrimonium Bromide (CTAB), a common used surfactant, act as a drug solubilizer with intrinsic antibacterial properties.
- GC16821TAE226(NVP-TAE226)CAS: 761437-28-9Purity: >98.00%
TAE226(NVP-TAE226) is a potent ATP-competitive inhibitor that inhibits a variety of tyrosine protein kinases, especially FAK and IGF-IR kinases, with IC 50 values of 5.5nM and 140nM, respectively.
- GC17239Bisindolylmaleimide VCAS: 113963-68-1Purity: >98%
negative control for protein kinase C (PKC)-inhibitory activity
- GC17242(-)-epigallocatechinCAS: 970-74-1Purity: >98.00%
(-)-epigallocatechin is a major polyphenolic compound in green tea with antioxidant properties.
- GC17243Dorsomorphin (Compound C)CAS: 866405-64-3Purity: >98.00%
Dorsomorphin (Compound C) is an agent that used as a cell-permeable AMPK inhibitor.
- GC17563LY 333531 hydrochlorideCAS: 169939-93-9Purity: >98.00%
Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM).
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC15471 | PKC β pseudosubstrate | 172308-76-8 | >98% | |
Selective cell-permeable peptide inhibitor of protein kinase C | ||||
| GC15564 | Go 6976 | 136194-77-9 | >98.00% | |
Go 6976 is a potent inhibitor of protein kinases (PKs), with IC 50 values of 0.02μM, 6.2μM, and 5.8μM for PKC, cGMP-dependent protein kinase, and myosin light-chain kinase, respectively. | ||||
| GC15567 | K02288 | 1431985-92-0 | >98.00% | |
ALK inhibitor | ||||
| GC15884 | Dasatinib Monohydrate | 863127-77-9 | >98% | |
Inhibitor of ABL, SRC, KIT, PDGFR, and other tyrosine kinases. | ||||
| GC15892 | Cetrimonium Bromide (CTAB) | 57-09-0 | >98.00% | |
Cetrimonium Bromide (CTAB), a common used surfactant, act as a drug solubilizer with intrinsic antibacterial properties. | ||||
| GC16289 | SAR407899 hydrochloride | 923262-96-8 | >98.00% | |
ATP-competitive ROCK inhibitor | ||||
| GC16405 | Safingol | 15639-50-6 | >98% | |
PKC and sphingosine kinases inhibitor | ||||
| GC16475 | Afuresertib | 1047644-62-1 | >99.50% | |
pan-AKT inhibitor | ||||
| GC16510 | ZIP, Biotinylated | - | >98% | |
ZIP with a biotin moiety covalently attached | ||||
| GC16539 | Butaprost | 69685-22-9 | >98.00% | |
A selective agonist for the EP 2 receptors | ||||
| GC16678 | UCN-02 | 121569-61-7 | >98% | |
protein kinase C inhibitor | ||||
| GC16793 | RepSox | 446859-33-2 | >98.00% | |
RepSox is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5) with an IC 50 of 23nM. RepSox inhibits ALK5 autophosphorylation with an IC 50 of 4nM. | ||||
| GC16821 | TAE226(NVP-TAE226) | 761437-28-9 | >98.00% | |
TAE226(NVP-TAE226) is a potent ATP-competitive inhibitor that inhibits a variety of tyrosine protein kinases, especially FAK and IGF-IR kinases, with IC 50 values of 5.5nM and 140nM, respectively. | ||||
| GC16934 | Valrubicin | 56124-62-0 | >99.50% | |
chemotherapy drug used to treat bladder cancer | ||||
| GC17014 | Ro 31-8220 Mesylate | 138489-18-6 | - | |
Pan-PKC inhibitor | ||||
| GC17191 | SIS3 HCl | 521984-48-5 | >98.00% | |
SIS3 HCl is a Smad3 inhibitor that inhibits the phosphorylation of Smad3 with an IC 50 of 3 μM. | ||||
| GC17239 | Bisindolylmaleimide V | 113963-68-1 | >98% | |
negative control for protein kinase C (PKC)-inhibitory activity | ||||
| GC17242 | (-)-epigallocatechin | 970-74-1 | >98.00% | |
(-)-epigallocatechin is a major polyphenolic compound in green tea with antioxidant properties. | ||||
| GC17243 | Dorsomorphin (Compound C) | 866405-64-3 | >98.00% | |
Dorsomorphin (Compound C) is an agent that used as a cell-permeable AMPK inhibitor. | ||||
| GC17346 | KT 5823 | 126643-37-6 | >95.00% | |
A protein kinase G inhibitor | ||||
| GC17352 | Phorbol 12,13-dibutyrate | 37558-16-0 | >99.50% | |
Protein kinase C activator | ||||
| GC17523 | Hydrochlorothiazide | 58-93-5 | >99.00% | |
diuretic drug of the thiazide class | ||||
| GC17563 | LY 333531 hydrochloride | 169939-93-9 | >98.00% | |
Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). | ||||
| GC17582 | ML347 | 1062368-49-3 | >98.00% | |
BMP receptor inhibitor,potent and selective | ||||