GLPBio

TGF-β / Smad Signaling

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Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

Research Areas

Products Related to TGF-β / Smad Signaling(358)

  • GC17591 structure
    GC17591D-erythro-Sphingosine (synthetic)
    CAS: 123-78-4
    Purity: >98.00%

    D-erythro-Sphingosine (synthetic) is a bioactive activator of p32 kinase (EC 50 =8μM).

  • GC17670 structure
    GC17670Bryostatin 1
    CAS: 83314-01-6
    Purity: >99.00%

    PKC activator

  • GC17712 structure
    GC17712AT13148
    CAS: 1056901-62-2
    Purity: >99.50%

    Multi-AGC kinase inhibitor,ATP-competitive

  • GC17727 structure
    GC17727[Ala107]-MBP (104-118)
    CAS: 99026-77-4
    Purity: >98%

    Non-competitive inhibitor of PKC

  • GC17767 structure
    GC17767Dihydrosphingosine
    CAS: 3102-56-5
    Purity: >98%

    Dihydrosphingosine is a potent inhibitor of PKC and phospholipase A2 (PLA2).

  • GC17815 structure
    GC17815L-threo-Sphingosine C-18
    CAS: 25695-95-8
    Purity: >98%

    L-threo-Sphingosine C-18 is a potent MAPK inhibitor. L-threo-Sphingosine C-18 induces apoptosis and clear DNA fragmentation. L-threo-Sphingosine C-18 shows anticancer effect.

  • GC17901 structure
    GC17901Tamoxifen
    CAS: 10540-29-1
    Purity: >98.00%

    Tamoxifen(TAM) serves as a selective estrogen receptor regulator (SERM), inhibiting estrogen's effects in breast cells while potentially stimulating estrogen activity in cells found in different tissues.

  • GC18015 structure
    GC18015LY2157299
    CAS: 700874-72-2
    Purity: >98.00%

    LY2157299 is an oral and selective TGF-β receptor type I (TGF-βRI) kinase inhibitor with an IC 50 value of 56nM.

  • GC18055 structure
    GC18055SC-9
    CAS: 102649-78-5
    Purity: >98%

    protein kinase C activator

  • GC18062 structure
    GC180621,2-Dilauroyl-sn-glycerol
    CAS: 60562-15-4
    Purity: >98%

    A longchain DAG

  • GC18246 structure
    GC18246R-59-949
    CAS: 120166-69-0
    Purity: >98.00%

    R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate.

  • GC18354 structure
    GC18354Bisindolylmaleimide X (hydrochloride)
    CAS: 145317-11-9
    Purity: >98.50%

    Bisindolylmaleimide X (hydrochloride) is a novel, cell-permeable protein kinase C (PKC) inhibitor. Bisindolylmaleimide X also inhibits cyclin-dependent kinase 2 (CDK2) activity.

  • GC18521 structure
    GC18521Cercosporin
    CAS: 35082-49-6
    Purity: >95.00%

    Cercosporin is a pigmented phytotoxin isolated from the fungus C.

  • GC19034 structure
    GC19034AR-13324 mesylate
    CAS: 1422144-42-0
    Purity: >98%

    AR-13324 mesylate is a potent inhibitor of Rho-associated protein kinases ROCK1 and ROCK2, with Kᵢ values of 1nM for both isoforms.

  • GC19177 structure
    GC19177GSK180736A
    CAS: 817194-38-0
    Purity: >99.50%

    GSK180736A is a G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 uM.

  • GC19234 structure
    GC19234LY3200882
    CAS: 1898283-02-7
    Purity: >99.50%

    LY3200882 is a novel and highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).

  • GC19338 structure
    GC19338SRI-011381 hydrochloride
    CAS: 2070014-88-7
    Purity: >98.00%

    SRI-011381 hydrochloride is an orally active activator of the transforming growth factor β (TGF-β) signaling pathway with neuroprotective effects.

  • GC19447 structure
    GC19447SM 16
    CAS: 614749-78-9
    Purity: >99.50%

    SM 16 is a ALK5/ALK4 kinase inhibitor

  • GC25482 structure
    GC25482GSK269962A HCl
    CAS: 2095432-71-4
    Purity: >98%

    GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

  • GC25662 structure
    GC25662N-Desmethyltamoxifen
    CAS: 31750-48-8
    Purity: >98%

    N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

  • GC25669 structure
    GC25669Nilotinib hydrochloride
    CAS: 923288-95-3
    Purity: >98%

    Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

  • GC26000 structure
    GC26000TP0427736 HCl
    CAS: 864374-00-5
    Purity: >98%

    TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.

  • GC26055 structure
    GC26055WAY-301398
    CAS: 312607-68-4
    Purity: >98%

    WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC).

  • GC26065 structure
    GC26065WAY-354831
    CAS: 330572-32-2
    Purity: >98%

    WAY-354831 exhibits antibacterial activity.