الصفحة الرئيسية>>Signaling Pathways>> Cell Cycle/Checkpoint>> Cytoskeleton & Motor Proteins>>16-epi Latrunculin B

16-epi Latrunculin B

رقم الكتالوجGC41110

16-epi Latrunculin B, first isolated from the Red Sea sponge N.

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16-epi Latrunculin B التركيب الكيميائي

Cas No.: 444911-05-1

الحجم السعر المخزون الكميّة
100μg
197٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 16-epi Latrunculin B

16-epi Latrunculin B, first isolated from the Red Sea sponge N. magnifica, is a stereoisomer of the actin polymerization inhibitor, latrunculin B . At 5-10 µg/ml, 16-epi latrunculin B can disrupt microfilament activity in an actin disruption assay. It also demonstrates cytotoxic activity in mouse KA31T and NIH3T3 tumor cells (GI50s = 1 and 4 µg/ml, respectively) and antiviral activity against herpes simplex type 1 virus (ED50 = 1 µg/ml).

Chemical Properties of 16-epi Latrunculin B

Cas No. 444911-05-1 SDF
Canonical SMILES C/C(CC/C=C\[C@H]1C)=C/C(O[C@H]2C[C@@]([C@]3([H])NC(SC3)=O)(O)O[C@H](CC1)C2)=O
Formula C20H29NO5S M.Wt 395.5
الذوبان DMSO: soluble,Ethanol: soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 16-epi Latrunculin B

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5284 mL 12.6422 mL 25.2845 mL
5 mM 0.5057 mL 2.5284 mL 5.0569 mL
10 mM 0.2528 mL 1.2642 mL 2.5284 mL
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In vivo Formulation Calculator (Clear solution) of 16-epi Latrunculin B

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Review for 16-epi Latrunculin B

Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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