2′-Deoxy-β-L-uridine |
| رقم الكتالوجGC67384 |
2'؛ -Deoxy-β؛ -L-uridine هو نظير نووي وركيزة محددة للإنزيم الفيروسي ، ولا يُظهر أي خصوصية مفرغة ضد الهربس البسيط 1 (HSV1) ثيميدين كيناز (TK). 2′؛ -Deoxy-β؛ -L-uridine يمارس نشاطًا مضادًا للفيروسات عن طريق تداخل 5' ؛ - ثلاثي فوسفات مع بوليميريز الحمض النووي الفيروسي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 31501-19-6
Sample solution is provided at 25 µL, 10mM.
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2'-Deoxy-β-L-uridine is a nucledside analogue and a specific substrate for the viral enzyme, shows no stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine exerts antiviral activity via the interation of 5'-triphosphates with the viral DNA polymerase[1][2].
[1]. Spadari S, et al. L-thymidine is phosphorylated by herpes simplex virus type 1 thymidine kinase and inhibits viral growth. J Med Chem. 1992 Oct 30;35(22):4214-20.
[2]. Lin TS, et al. Design and synthesis of 2',3'-dideoxy-2',3'-didehydro-beta-L-cytidine (beta-L-d4C) and 2',3'-dideoxy 2',3'-didehydro-beta-L-5-fluorocytidine (beta-L-Fd4C), two exceptionally potent inhibitors of human hepatitis B virus (HBV) and potent inhibitors of human immunodeficiency virus (HIV) in vitro. J Med Chem. 1996 Apr 26;39(9):1757-9.
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