(2S,3S)-E1R |
| رقم الكتالوجGC38714 |
(2S ، 3S) -E1R (المركب 2d) هو متماثل لـ E1R
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Cas No.: 1424832-57-4
Sample solution is provided at 25 µL, 10mM.
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(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].
Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer's disease, major depressive disorders, and schizophrenia[1].
[1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71.
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