الصفحة الرئيسية>>Signaling Pathways>> Microbiology & Virology>> Virus Protease>>3,4-Dimethoxycinnamic acid (O-Methylferulic acid)

3,4-Dimethoxycinnamic acid (O-Methylferulic acid)

رقم الكتالوجGC33992

حمض 3،4-ديميثوكسيسيناميك (O-Methylferulic acid) (O-Methylferulic acid) هو مونومر مستخلص من Securidaca inappendiculata Hassk.

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3,4-Dimethoxycinnamic acid (O-Methylferulic acid) التركيب الكيميائي

Cas No.: 2316-26-9

الحجم السعر المخزون الكميّة
100mg
46٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 3,4-Dimethoxycinnamic acid (O-Methylferulic acid)

3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].

3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells[1].3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner[1].

[1]. Li L, et al. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signalingpathway. Int J Oncol. 2018 Jul;53(1):225-236.

Chemical Properties of 3,4-Dimethoxycinnamic acid (O-Methylferulic acid)

Cas No. 2316-26-9 SDF
Canonical SMILES O=C(O)/C=C/C1=CC=C(OC)C(OC)=C1
Formula C11H12O4 M.Wt 208.21
الذوبان DMSO : 50 mg/mL (240.14 mM; Need ultrasonic) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 3,4-Dimethoxycinnamic acid (O-Methylferulic acid)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.8028 mL 24.0142 mL 48.0284 mL
5 mM 0.9606 mL 4.8028 mL 9.6057 mL
10 mM 0.4803 mL 2.4014 mL 4.8028 mL
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In vivo Formulation Calculator (Clear solution) of 3,4-Dimethoxycinnamic acid (O-Methylferulic acid)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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