3-Methoxycatechol (Synonyms: 1,2-Dihydroxy-3-methoxybenzene, 3-Methoxypyrocatechol, NSC 66525, Pyrogallol 1-monomethyl ether) |
| رقم الكتالوجGC49874 |
A lignan-derived phenol
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 934-00-9
Sample solution is provided at 25 µL, 10mM.
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3-Methoxycatechol is a lignan-derived phenol.1 It is an agonist of G protein-coupled receptor 35 (GPR35) with an EC50 value of 147 µM in a dynamic mass redistribution (DMR) assay using HT-29 cells.2 Dietary administration of 3-methoxycatechol (2%) alone, or in a model of multiorgan carcinogenesis induced by nitrosamines, promotes esophageal carcinogenesis in rats.3 3-Methoxycatechol has been used as a precursor in the enzymatic synthesis of the phenols pyrogallol and purpurogallin and in the electro-organic synthesis of coumestan derivatives.1,4
1.Zhang, S., Xiaofeng, W., and Xiao, Y.Conversion of lignin-derived 3-methoxycatechol to the natural product purpurogallin using bacterial P450 GcoAB and laccase CueOAppl. Microbiol. Biotechnol.106(2)593-603(2022) 2.Deng, H., and Fang, Y.The three tatecholics benserazide, catechol and pyrogallol are GPR35 agonistsPharmaceuticals (Basel)6(4)500-509(2013) 3.Hirose, M., Tnaka, H., Takahashi, S., et al.Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis modelCancer Res.53(1)32-37(1993) 4.Golabi, S.M., and Nematollahi, D.Electrochemical study of catechol and some 3-substituted catechols in the prescence of 4-hydroxy coumarin: Application to the electro-organic synthesis of new coumestan derivativesJ. Electroanal. Chem.420(1-2)127-134(1997)
| Cas No. | 934-00-9 | SDF | |
| المرادفات | 1,2-Dihydroxy-3-methoxybenzene, 3-Methoxypyrocatechol, NSC 66525, Pyrogallol 1-monomethyl ether | ||
| Canonical SMILES | OC1=CC=CC(OC)=C1O | ||
| Formula | C7H8O3 | M.Wt | 140.1 |
| الذوبان | DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): 2 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 7.1378 mL | 35.6888 mL | 71.3776 mL |
| 5 mM | 1.4276 mL | 7.1378 mL | 14.2755 mL |
| 10 mM | 0.7138 mL | 3.5689 mL | 7.1378 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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