4,4'-Dimethoxybenzil (p-Anisil) |
| رقم الكتالوجGC33328 |
4،4' ؛ -Dimethoxybenzil (p-Anisil) هو مثبط كربوكسيل إستراز معوي بشري (hiCE) مع Ki من 70 نانومتر.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1226-42-2
Sample solution is provided at 25 µL, 10mM.
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4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM.
By reducing irinotecaninduced diarrhea, hiCE inhibitors (e.g., 4,4'-Dimethoxybenzil, Compound 8) can improve the anti-cancer efficacy of irinotecan. To find effective hiCE inhibitors, a new virtual screening protocol that combines pharmacophore models derived from the hiCE structure and its ligands has been proposed[1].
[1]. GuoDong Zhang, et al. Predicting hiCE inhibitors based upon pharmacophore models derived from the receptor and its ligands. Science China Chemistry
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