الصفحة الرئيسية>>Signaling Pathways>> Toxins>> Mycotoxins>>4-deoxy Nivalenol-13C15

4-deoxy Nivalenol-13C15 (Synonyms: Vomitoxin-13C15, Deoxynivalenol-13C15, DON-13C15)

رقم الكتالوجGC46635

An internal standard for the quantification of 4-deoxy nivalenol

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4-deoxy Nivalenol-13C15 التركيب الكيميائي

Cas No.: 911392-36-4

الحجم السعر المخزون الكميّة
1.2 ml
1670٫00
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Sample solution is provided at 25 µL, 10mM.

Description of 4-deoxy Nivalenol-13C15

4-deoxy Nivalenol-13C15 is intended for use as an internal standard for the quantification of 4-deoxy nivalenol by GC- or LC-MS. 4-deoxy Nivalenol is a trichothecene mycotoxin that has been found in Fusarium.1 It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet.2 It induces lethality in mice (LD50 = 46-78 mg/kg).3 4-deoxy Nivalenol has been found in F. graminearum-infected cereal grains such as wheat, barley, and corn.

1.Pestka, J.J., and Smolinski, A.T.Deoxynivalenol: Toxicology and potential effects on humansJ.Toxicol.Environ.Health B.Crit.Rev.8(1)39-69(2005) 2.Forsyth, D.M., Yoshizawa, T., Morooka, N., et al.Emetic and refusal activity of deoxynivalenol to swineAppl. Environ. Microbiol.34(5)547-552(1977) 3.Pestka, J.J.Deoxynivalenol: Mechanisms of action, human exposure, and toxicological relevanceArch. Toxicol.84(9)663-679(2010)

Chemical Properties of 4-deoxy Nivalenol-13C15

Cas No. 911392-36-4 SDF
المرادفات Vomitoxin-13C15, Deoxynivalenol-13C15, DON-13C15
Canonical SMILES [13CH3][13C]1=[13CH][13C@]2([H])[13C@]([13C@]([13CH2][13C@H]3O)([13CH3])[13C@]4([13CH2]O4)[13C@]3([H])O2)([13CH2]O)[13C@H](O)[13C]1=O
Formula [13C]15H20O6 M.Wt 311.2
الذوبان Ethanol : 30 mg/mL (96.40 mM; Need ultrasonic and warming); DMSO : 25 mg/mL (80.33 mM; Need ultrasonic and warming) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 4-deoxy Nivalenol-13C15

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.2134 mL 16.0668 mL 32.1337 mL
5 mM 0.6427 mL 3.2134 mL 6.4267 mL
10 mM 0.3213 mL 1.6067 mL 3.2134 mL
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In vivo Formulation Calculator (Clear solution) of 4-deoxy Nivalenol-13C15

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

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