5-fluoro NNEI (Synonyms: 5-fluoro MN-24) |
رقم الكتالوجGC18215
One-Click Copy Product Info
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JWH 018 is a potent synthetic cannabinoid (CB) which has been identified in smoking mixtures.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1445580-60-8
Sample solution is provided at 25 µL, 10mM.
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JWH 018 is a potent synthetic cannabinoid (CB) which has been identified in smoking mixtures.[1] [2] NNEI is an analog of JWH 018 which differs by having an amide linker inserted between the naphthalene and ketone groups. 5-fluoro NNEI is a derivative of NNEI in which a fluorine atom has been added to the terminal carbon of the pentyl chain. This modification of other synthetic CBs typically increases the compound’s affinity for both CB receptors significantly. [3] The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
Reference:
[1]. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).
[2]. Moran, C.L., Le, V.H., Chimalakonda, K.C., et al. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine. Anal. Chem. 83(11), 4228-4236 (2011).
[3]. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives. PCT/US00/28832, (2001).
| Cas No. | 1445580-60-8 | SDF | |
| المرادفات | 5-fluoro MN-24 | ||
| Chemical Name | 1-(5-fluoropentyl)-N-(naphthalen-1-yl)-1H-indole-3-carboxamide | ||
| Canonical SMILES | O=C(C1=CN(CCCCCF)C2=C1C=CC=C2)NC3=C(C=CC=C4)C4=CC=C3 | ||
| Formula | C24H23FN2O | M.Wt | 374.5 |
| الذوبان | 5mg/mL in DMSO, 3.3mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6702 mL | 13.3511 mL | 26.7023 mL |
| 5 mM | 534 μL | 2.6702 mL | 5.3405 mL |
| 10 mM | 267 μL | 1.3351 mL | 2.6702 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)