α-CGRP (8-37) (human) (trifluoroacetate salt) (Synonyms: Calcitonin Gene-Related Peptide-1 (8-37) (human), CGRP-1 (8-37) (human), α-Calcitonin Gene-Related Peptide (8-37) (human)) |
| رقم الكتالوجGC45198 |
Calcitonin gene-related protein (CGRP) is a neuropeptide and a product of alternative splicing of the calcitonin gene.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Calcitonin gene-related protein (CGRP) is a neuropeptide and a product of alternative splicing of the calcitonin gene. It induces vasodilation of both arteries and veins in addition to various non-vascular biological activities. α-CGRP (8-37) is an antagonist of CGRP receptors (IC50 = 4.9 nM in SK-N-MC cells expressing the human receptor) that inhibits CGRP-induced vasodilation. In a mouse model of headache, α-CGRP (8-37) application to the dura mater reduces behavior induced by application of capsaicin and inflammatory mediators. α-CGRP (8-37) (human) is a peptide fragment derived from the human CGRP protein sequence.
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