الصفحة الرئيسية>>Signaling Pathways>> Immunology/Inflammation>> Reactive Oxygen Species>>β-BHC

β-BHC (Synonyms: β-HCH, β-Hexachlorocyclohexane, β-Lindane)

رقم الكتالوجGC45226

β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.

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β-BHC التركيب الكيميائي

Cas No.: 319-85-7

الحجم السعر المخزون الكميّة
5mg
33٫00
متوفر
10mg
56٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of β-BHC

β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane. It is estrogenic, inducing estrogen receptor α (ERα) and ERβ reporter gene expression in CHO cells expressing the human receptors with 20% relative effective concentration (REC20) values of 3.5 and 1.1 μM, respectively. In vitro, β-BHC induces apoptosis of rat Sertoli cells via production of reactive oxygen species (ROS), activation of caspases, and induction of expression of Fas ligand (FasL). It is a persistent organic pollutant and levels of total body β-BHC are negatively correlated to plasma testosterone levels in male polar bears.

Chemical Properties of β-BHC

Cas No. 319-85-7 SDF
المرادفات β-HCH, β-Hexachlorocyclohexane, β-Lindane
Canonical SMILES Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@@H](Cl)[C@@H]1Cl
Formula C6H6Cl6 M.Wt 290.8
الذوبان DMSO: Slightly Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of β-BHC

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.4388 mL 17.1939 mL 34.3879 mL
5 mM 0.6878 mL 3.4388 mL 6.8776 mL
10 mM 0.3439 mL 1.7194 mL 3.4388 mL
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In vivo Formulation Calculator (Clear solution) of β-BHC

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 32 reference(s) in Google Scholar.)

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