Aclidinium Bromide (Synonyms: LAS 34273, LAS-W 330) |
رقم الكتالوجGC14096
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بروميد أكليدينيوم (LAS 34273 ؛ LAS-W 330) هو مضاد مسكاريني طويل المفعول يتم استنشاقه
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 320345-99-1
Sample solution is provided at 25 µL, 10mM.
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Aclidinium Bromide is a long-acting antagonist of muscarinic (LAMAs) [1].
Aclidinium Bromide has been reported to inhibit the specific binding of [3H]-NMS to human M receptors in a dose-denpendent fasion with Ki values of 0.10±0.00nM,0.14±0.04nM, 0.14±0.02nM, 0.21±0.04nM and 0.16±0.01nM for M1, M2,M3,M4 and M5, respectively. In addition, Aclidinium Bromide has shown the great potency at endogenous M2 and M3 receptors with EC50 values of 17.4±1.1nM and 5.3±1.6nM, respectively. Apart from these, Aclidinium Bromide has been revealed to produce a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction in vivo with an EC50 of ranging from 2.5 to 23.1μg/mL in anaesthetized guines pigs. Besides, Aclidinium Bromide has also been noted to inhibit the salivation in rat pilocarpine-induced sialorrhea model with an EC50 of 38μg/kg [1].
References:
[1] Gavaldà A1, Ramos I2, Carcasona C3, Calama E4, Otal R5, Montero JL6, Sentellas S7, Aparici M8, Vilella D9, Alberti J10, Beleta J11, Miralpeix M12. The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide. Pulm Pharmacol Ther. 2014 Aug;28(2):114-21.
| Cas No. | 320345-99-1 | SDF | |
| المرادفات | LAS 34273, LAS-W 330 | ||
| Chemical Name | [(3R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate;bromide | ||
| Canonical SMILES | C1C[N+]2(CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5.[Br-] | ||
| Formula | C26H30BrNO4S2 | M.Wt | 564.55 |
| الذوبان | ≥ 28.2275mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7713 mL | 8.8566 mL | 17.7132 mL |
| 5 mM | 354.3 μL | 1.7713 mL | 3.5426 mL |
| 10 mM | 177.1 μL | 885.7 μL | 1.7713 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)